染色体易位的分子机制

发布时间：2019-04-17 20:34

【摘要】：染色体易位是一种严重的基因组缺陷,其主要产生原因是DNA的双链断裂发生了错误修复。临床上染色体易位在肿瘤的发生发展过程中扮演了十分关键的角色。虽然对这方面的研究在最近四十年一直被报道,但是染色体易位在细胞内形成的内在机制还有待进一步深入研究和探讨。近年来的研究已经阐明了描述了染色体易位形成的步骤,同时也发现在易位形成的过程中,各种因素包括DNA双链断裂修复系统、染色体结构和空间位置、组蛋白修饰等在引起染色体易位频率增加和断裂末端的配对接触的过程中都发挥了重要作用。本研究就近年来对于染色体易位分子机制的研究进行概述,初步总结讨论染色体易位形成的原因、过程以及各部分对易位的形成的作用影响。
[Abstract]:Chromosome translocation is a serious genomic defect, the main cause of which is the wrong repair of double strand breaks of DNA. Chromosome translocation plays a key role in the carcinogenesis and development of tumors. Although studies on this field have been reported in the last 40 years, the intrinsic mechanism of chromosome translocation in cells needs to be further studied and discussed. In recent years, studies have elucidated the steps of chromosome translocation formation, and found that in the process of translocation, various factors include DNA double strand break repair system, chromosome structure and spatial location. Histone modification plays an important role in the process of increasing the frequency of chromosome translocation and the pairing of broken ends. This study summarized the molecular mechanism of chromosome translocation in recent years, and discussed the causes, processes and effects of each part on the formation of chromosome translocation in recent years, and discussed the reasons for the formation of chromosome translocation, the process and the effects of each part on the formation of chromosome translocation.
【作者单位】：中南大学湘雅医学院医学检验系;
【基金】：国家自然科学基金(81273002;81471499) 国家重大科学仪器专项子课题(2012YQ030261)共同资助
【分类号】：R730.2

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