外周血IL-6对早期肝癌微波消融后复发的预测
发布时间：2019-04-25 17:32
【摘要】：目的探讨血清中白细胞介素-6(IL-6)和IL-22对早期乙型病毒性肝炎相关肝细胞癌患者(HBV-HCC)微波消融(MWA)治疗后复发的预测作用。方法收集49例经MWA治疗早期HBVHCC患者术前外周血,应用ELISA检测外周血IL-6与IL-22的含量,同期30例健康人作对照。据x-tile软件计算cut-off值将IL-6和IL-22水平分为高水平组和低水平组,Kaplan-Meier分析两组的无瘤生存期,Log rank检验差异性,Cox回归筛选影响HBV-HCC复发的危险因素。结果 HCC组的IL-6与IL-22水平明显高于对照组(IL-6:13.20(11.87~15.79)pg/ml和10.47(9.50~13.82)pg/ml,P=0.001;IL-22:42.18(34.39~57.44)pg/ml和25.45(22.31~30.12)pg/ml,P0.001)。Kaplan-Meier分析显示HCC患者术前低IL-6、高总胆红素和低白蛋白水平预示较短无瘤生存期,IL-22对HCC复发的影响差异无统计学意义。Cox回归多因素分析显示低IL-6(≤13.2 pg/ml,HR:3.721,95%CI:1.674~8.272,P=0.001)与低白蛋白水平(≤41.0 g/L,HR:2.085,95%CI:1.101~3.950,P=0.024)是影响肝癌复发的独立危险因素。结论术前IL-6和白蛋白水平可作为MWA治疗HBV-HCC患者预测复发的指标。
[Abstract]:Objective to investigate the predictive effect of serum interleukin-6 (IL-6) and IL-22 on recurrence after microwave ablation of (MWA) in patients with early hepatitis B-associated hepatocellular carcinoma (HBV-HCC). Methods Peripheral blood samples were collected from 49 patients with early HBVHCC treated with MWA. The levels of IL-6 and IL-22 in peripheral blood were measured by ELISA, and 30 healthy subjects were served as control at the same time. According to cut-off calculated by x-tile software, IL-6 and IL-22 levels were divided into two groups: high level group and low level group. The difference of, Log rank test for tumor-free survival between the two groups was analyzed by Kaplan-Meier. The risk factors of HBV-HCC recurrence were screened by Cox regression. Results the levels of IL-6 and IL-22 in HCC group were significantly higher than those in control group (IL-6:13.20 (11.87? 15.79) pg/ml and 10.47 (9.50? 13.82) pg/ml,P=0.001;). IL-22:42.18 (34.39? 57.44) pg/ml and 25.45 (22.31? 30.12) pg/ml,P0.001. Kaplan-Meier analysis showed that low IL-6, high total bilirubin and low albumin levels predicted shorter tumor-free survival time in patients with HCC. Cox regression multivariate analysis showed that low IL-6 (鈮，
本文编号：2465322
[Abstract]:Objective to investigate the predictive effect of serum interleukin-6 (IL-6) and IL-22 on recurrence after microwave ablation of (MWA) in patients with early hepatitis B-associated hepatocellular carcinoma (HBV-HCC). Methods Peripheral blood samples were collected from 49 patients with early HBVHCC treated with MWA. The levels of IL-6 and IL-22 in peripheral blood were measured by ELISA, and 30 healthy subjects were served as control at the same time. According to cut-off calculated by x-tile software, IL-6 and IL-22 levels were divided into two groups: high level group and low level group. The difference of, Log rank test for tumor-free survival between the two groups was analyzed by Kaplan-Meier. The risk factors of HBV-HCC recurrence were screened by Cox regression. Results the levels of IL-6 and IL-22 in HCC group were significantly higher than those in control group (IL-6:13.20 (11.87? 15.79) pg/ml and 10.47 (9.50? 13.82) pg/ml,P=0.001;). IL-22:42.18 (34.39? 57.44) pg/ml and 25.45 (22.31? 30.12) pg/ml,P0.001. Kaplan-Meier analysis showed that low IL-6, high total bilirubin and low albumin levels predicted shorter tumor-free survival time in patients with HCC. Cox regression multivariate analysis showed that low IL-6 (鈮，
本文编号：2465322
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