扶正散结方对非小细胞肺癌的抑瘤作用及对血清VEGF,TSGF的调控机制

发布时间：2019-05-09 01:12

【摘要】：目的:探讨扶正散结方对非小细胞肺癌的抑瘤及对血清血管内皮生长因子(vascular endothelial growth factor,VEGF),肿瘤特异性生长因子(tumor specific growth factor,TSGF)的调控作用。方法:选取130例非小细胞肺癌患者,随机分为化疗组(A组,32例),综合组(扶正散结方+化疗组,B组,48例)和扶正散结方组(C组,50例),分析各组治疗后疗效、复发转移及转移灶情况、中医证候及生活质量改善情况及对血清VEGF,TSGF的调控作用。结果:B组控显率达79.2%,明显高于A,C两组(P0.05);治疗后A,B,C组的转移灶缩小者分别为46.8%,75.0%,44.0%;服用扶正散结方组新转移灶发生率明显低于未服用的单纯化疗组(P0.05);在中医证候方面,3组中以B组(79.1%)改善最为明显(P0.05);B组舌质、舌苔也较单纯化疗组改善明显(P0.05);3组患者治疗前血清VEGF,TSGF平均水平均高于正常值。与治疗前比较,治疗后C,B组血清VEGF水平明显下降(P0.05,P0.01);3组治疗后TSGF水平均有所下降(P0.05)。结论:扶正散结方能够减轻化疗副作用,改善临床症状,提高生存质量,同时能使血清VEGF,TSGF水平下降,减少肿瘤转移的发生。
[Abstract]:Aim: to investigate the inhibitory effect of Fuzheng Sanjie recipe on non-small cell lung cancer (NSCLC) and the regulation of vascular endothelial growth factor (vascular endothelial growth factor,VEGF) and tumor specific growth factor (tumor specific growth factor,TSGF) in patients with non-small cell lung cancer (NSCLC). Methods: 130 patients with non-small cell lung cancer were randomly divided into chemotherapy group (group A, 32 cases), comprehensive group (group B, 48 cases) and group C (group C, 50 cases). Recurrence, metastasis and metastasis, TCM syndrome and quality of life improvement and regulation of serum VEGF,TSGF. Results: the control rate was 79.2% in group B, which was significantly higher than that in group A and C (P0.05), and the reduction of metastatic focus in group A, B and C was 46.8%, 75.0%, 44.0% after treatment, respectively. The incidence of new metastases in Fuzheng Sanjie recipe group was significantly lower than that in untaken chemotherapy group (P 0.05). In terms of TCM syndromes, group B (79.1%) improved most significantly (P 0.05). The tongue quality and coating of tongue in group B were significantly improved compared with those in group B (P0.05), and the average level of serum VEGF,TSGF was higher than that of normal group before treatment in group B (P0.05). After treatment, the level of serum VEGF in group C and B was significantly lower than that before treatment (P0.05, P0.01), and the level of TSGF in three groups was decreased after treatment (P0.05). Conclusion: Fuzheng Sanjie recipe can reduce the side effects of chemotherapy, improve the clinical symptoms and improve the quality of life. At the same time, it can reduce the level of serum VEGF,TSGF and reduce the occurrence of tumor metastasis.
【作者单位】：天津中医药大学第一附属医院;
【基金】：天津市卫生局课题项目(2005038)
【分类号】：R734.2

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