碘-125粒子条腔内近程放射治疗局部进展期胰腺导管腺癌伴梗阻性黄疸的初步临床研究
发布时间：2019-06-06 02:31
【摘要】：目的探索碘-125粒子条腔内近程放射治疗局部进展期胰腺导管腺癌伴梗阻性黄疸的安全性及可行性。方法对2010年1月至2015年2月复旦大学附属中山医院介入科收治的17例局部进展期(4例为T4N0M0,13例为T4N1M0)胰腺导管腺癌伴梗阻性黄疸患者行碘-125粒子条腔内近程放射治疗的临床资料进行回顾性分析。用配对t检验分析患者术前、术后肝功能变化。碘-125粒子条放射剂量由碘-125粒子条放射区域分布计算软件(0.1版,复旦大学影像研究所)根据美国医学物理协会TG43U1近程放射公式计算。用Kaplan-Meier曲线分析无梗阻生存期和累计生存期。术后并发症根据美国国立癌症研究所通用毒性标准4.0版评估。结果碘-125粒子条累计剂量(r=5 mm,240天)为164.19~170.05 Gy,平均为167.38Gy。平均、中位无梗阻生存期分别为(9.62±1.47)个月(95%CI:6.73~12.50)和(7.26±1.71)个月(95%CI:3.90~10.62),平均、中位总生存期分别为(9.89±1.59)个月(95%CI:6.78~13.00)和(7.26±1.71)个月(95%CI:3.90~10.62)。患者术前、术后总胆红素和直接胆红素差异具有统计学意义。研究中2例患者发生3级术后并发症,1例患者发生4级并发症。1例患者出现支架再狭窄(5.9%)。结论碘-125粒子条腔内近程放射治疗是局部进展期胰腺导管腺癌伴梗阻性黄疸的一种安全可行的治疗方法。
[Abstract]:Objective to investigate the safety and feasibility of iodine-125 particle intracavitary short-range radiotherapy in the treatment of locally advanced pancreatic ductal carcinoma with obstructive jaundice. Methods from January 2010 to February 2015, 17 patients (4 patients with T4N0M0, 13 patients with T4N1M0) with pancreatic ductal carcinoma complicated with obstructive jaundice were treated with iodine-125 particle intracavitary short-range radiotherapy in the Department of intervention, Zhongshan Hospital affiliated to Fudan University. The clinical data of radiation therapy were analyzed retrospectively. The changes of liver function before and after operation were analyzed by matched t test. The radiation dose of iodine-125 particle strip is calculated by the software for calculating the radiation area distribution of iodine-125 particle strip (version 0.1, Institute of Imaging, Fudan University) according to the TG43U1 short-range radiation formula of the American Association of Medical Physics. Kaplan-Meier curve was used to analyze the survival time without obstruction and cumulative survival time. Postoperative complications were assessed according to version 4.0 of the National Cancer Institute General toxicity Standard. Results the cumulative dose of iodine-125 particle strip (r 鈮，
本文编号：2494004
[Abstract]:Objective to investigate the safety and feasibility of iodine-125 particle intracavitary short-range radiotherapy in the treatment of locally advanced pancreatic ductal carcinoma with obstructive jaundice. Methods from January 2010 to February 2015, 17 patients (4 patients with T4N0M0, 13 patients with T4N1M0) with pancreatic ductal carcinoma complicated with obstructive jaundice were treated with iodine-125 particle intracavitary short-range radiotherapy in the Department of intervention, Zhongshan Hospital affiliated to Fudan University. The clinical data of radiation therapy were analyzed retrospectively. The changes of liver function before and after operation were analyzed by matched t test. The radiation dose of iodine-125 particle strip is calculated by the software for calculating the radiation area distribution of iodine-125 particle strip (version 0.1, Institute of Imaging, Fudan University) according to the TG43U1 short-range radiation formula of the American Association of Medical Physics. Kaplan-Meier curve was used to analyze the survival time without obstruction and cumulative survival time. Postoperative complications were assessed according to version 4.0 of the National Cancer Institute General toxicity Standard. Results the cumulative dose of iodine-125 particle strip (r 鈮，
本文编号：2494004
本文链接：https://www.wllwen.com/yixuelunwen/zlx/2494004.html
