小细胞性肺癌患者检测抗纺锤体抗体和抗着丝点抗体的临床意义
发布时间：2019-06-09 21:48
【摘要】：目的:研究抗纺锤体(MSA)和抗着丝点(ACA)抗体检测对诊断小细胞性肺癌(SCLC)的临床价值,为SCLC的分子研究提供临床依据。方法:对93例SCLC患者和208例非小细胞性肺癌(NO-SCLC)患者及50例健康体检者,用酶联免疫法定量检测MSA抗体,间接免疫荧光法定性检测MSA、ACA和抗核抗体(ANA),并对其结果进行回顾性分析。结果:1IIF法检测SCLC组MSA和ACA阳性率为36.56%和30.11%,均高于其他肿瘤组(P0.01)。2相关性分析,MSA与SCLC的RR值高达12.93、12.74,ACA和ANA与SCLC的RR值为4.31和3.48。3MSA检测SCLC的ROC曲线下面积AUC为0.778,诊断价值中等。结论:MSA和ACA对SCLC有很强正相关危险因素,可能参与SCLC的发生发展,对SCLC的早期检测、临床诊断及潜在的治疗方法有一定的应用价值。
[Abstract]:Objective: to study the clinical value of antispindle (MSA) and anti-centromere (ACA) antibody in the diagnosis of small cell lung cancer (SCLC), and to provide clinical basis for the molecular study of SCLC. Methods: MSA antibody was detected quantitatively by enzyme-linked immunosorbent assay (Elisa) in 93 patients with SCLC, 208 patients with non-small cell lung cancer (NO-SCLC) and 50 healthy controls. MSA,ACA and antinuclear antibody (ANA), were detected qualitatively by indirect immunofluorescence assay. The results were analyzed retrospectively. Results: the positive rates of MSA and ACA in SCLC group were 36.56% and 30.11%, which were higher than those in other tumor groups (P01). 2 correlation analysis showed that the RR value of MSA and SCLC was 12.93 and 12.74, respectively. The RR values of ACA, ANA and SCLC were 4.31 and the area AUC under ROC curve of SCLC detected by 3.48.3MSA was 0.778, which was of medium diagnostic value. Conclusion: MSA and ACA have strong positive correlation risk factors for SCLC, may be involved in the occurrence and development of SCLC, and have certain application value for early detection, clinical diagnosis and potential treatment of SCLC.
【作者单位】： 南昌大学第二附属医院检验科;南昌大学医学院;
【基金】：江西省科技厅社发项目(No.2015BBG70154) 江西省科技厅重点科技成果转移转化计划(No.20151BBI90047) 江西省卫生厅科研计划支持项目(No.20133075、20151072)
【分类号】：R734.2
本文编号：2495929
[Abstract]:Objective: to study the clinical value of antispindle (MSA) and anti-centromere (ACA) antibody in the diagnosis of small cell lung cancer (SCLC), and to provide clinical basis for the molecular study of SCLC. Methods: MSA antibody was detected quantitatively by enzyme-linked immunosorbent assay (Elisa) in 93 patients with SCLC, 208 patients with non-small cell lung cancer (NO-SCLC) and 50 healthy controls. MSA,ACA and antinuclear antibody (ANA), were detected qualitatively by indirect immunofluorescence assay. The results were analyzed retrospectively. Results: the positive rates of MSA and ACA in SCLC group were 36.56% and 30.11%, which were higher than those in other tumor groups (P01). 2 correlation analysis showed that the RR value of MSA and SCLC was 12.93 and 12.74, respectively. The RR values of ACA, ANA and SCLC were 4.31 and the area AUC under ROC curve of SCLC detected by 3.48.3MSA was 0.778, which was of medium diagnostic value. Conclusion: MSA and ACA have strong positive correlation risk factors for SCLC, may be involved in the occurrence and development of SCLC, and have certain application value for early detection, clinical diagnosis and potential treatment of SCLC.
【作者单位】： 南昌大学第二附属医院检验科;南昌大学医学院;
【基金】：江西省科技厅社发项目(No.2015BBG70154) 江西省科技厅重点科技成果转移转化计划(No.20151BBI90047) 江西省卫生厅科研计划支持项目(No.20133075、20151072)
【分类号】：R734.2
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