地塞米松预防肺癌骨转移患者姑息放疗导致疼痛加重的临床研究
发布时间：2019-06-18 11:36
【摘要】：目的:探讨地塞米松在有效缓解肺癌骨转移患者姑息放疗导致的疼痛加重及其安全性。方法:选取山东大学附属千佛山医院2011年1月至2016年4月收治的103例肺癌骨转移患者随机分为地塞米松(观察组)和安慰剂(对照组)治疗,其中观察组51例,对照组52例,分别于放疗后给予地塞米松(5 mg,iv)/安慰剂(生理盐水1 m L,iv)治疗,比较两组患者放疗后疼痛情况。结果:观察组的51例患者中13例(25%)发生疼痛加重;对照组的52例患者中20例(38%)发生疼痛加重(P=0.03)。结论:地塞米松可减少肺癌骨转移放疗引起的疼痛加重,该结论仍需进一步的研究证实。
[Abstract]:Objective: to investigate the safety of dexamethasone in relieving pain aggravation caused by palliative radiotherapy in patients with bone metastasis of lung cancer. Methods: from January 2011 to April 2016, 103 patients with bone metastasis of lung cancer were randomly divided into dexamethasone (observation group) and placebo (control group). 51 patients in the observation group and 52 patients in the control group were treated with dexamethasone (5 mg,iv) / placebo (saline 1 mL, iv). The pain after radiotherapy was compared between the two groups. Results: pain aggravation occurred in 13 (25%) of 51 patients in the observation group and 20 (38%) in the control group (P 鈮，
本文编号：2501455
[Abstract]:Objective: to investigate the safety of dexamethasone in relieving pain aggravation caused by palliative radiotherapy in patients with bone metastasis of lung cancer. Methods: from January 2011 to April 2016, 103 patients with bone metastasis of lung cancer were randomly divided into dexamethasone (observation group) and placebo (control group). 51 patients in the observation group and 52 patients in the control group were treated with dexamethasone (5 mg,iv) / placebo (saline 1 mL, iv). The pain after radiotherapy was compared between the two groups. Results: pain aggravation occurred in 13 (25%) of 51 patients in the observation group and 20 (38%) in the control group (P 鈮，
本文编号：2501455
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