居住环境及室内空气污染与肺癌发病关系病例对照研究

发布时间：2019-06-21 04:54

【摘要】：目的了解居住环境及室内空气污染与肺癌发病的关系。方法采用病例对照研究方法对2006年1月-2014年12月在福建医科大学附属第一医院、附属协和医院、南京军区福州总医院经病理确诊的1 374例新发肺癌患者和同期到医院非肿瘤科室访视的按性别、年龄(±2岁)频数匹配的1374名健康对照人群进行问卷调查。结果病例组肺癌患者居住地附近企业污染类型为废气污染、废水污染、粉尘污染、多种污染、其他污染、家庭被动吸烟、10年前烹调燃料为煤烟型、近10年烹调燃料为煤烟型、室内烹调油烟量很少、有些、很多、厨房与卧室不分开、居室通风情况一般、差的比例分别为10.20%、3.2%、2.2%、2.6%、1.5%、46.5%、40.2%、11.6%、54.7%、23.8%、4.5%、2.9%、18.5%、3.3%,均高于对照组健康人群的4.2%、0.9%、0.5%、0.7%、0.6%、25.7%、22.9%、5.2%、48.3%、18.7%、1.7%、1.5%、9.0%、1.2%(均P0.05);病例组肺癌患者使用排风扇或抽油烟机、炒菜时油温中等热、住宅类型为楼房的比例分别为58.8%,63.3%、67.6%,均低于对照组健康人群的75.3%、70.2%、86.8%(均P0.05);在调整性别、年龄、民族、文化程度、婚姻状况、体质指数、吸烟情况、职业危险因素暴露史、肿瘤家族史、肺部疾病史等混杂因素后,多因素非条件logistic回归分析结果显示,居住地附近企业污染类型为废气、废水、粉尘和多种污染、家庭被动吸烟、10年前烹调燃料为煤烟型、室内烹调有油烟和居室通风不良是肺癌发病的危险因素,炒菜时油温中等热和住宅类型为楼房是肺癌发病的保护因素。结论居住环境及室内空气污染可增加肺癌的发病风险。
[Abstract]:Objective to investigate the relationship between living environment and indoor air pollution and the incidence of lung cancer. Methods A case-control study was conducted to investigate 1374 new lung cancer patients diagnosed pathologically in the first affiliated Hospital of Fujian Medical University, affiliated Union Medical College Hospital and Fuzhou General Hospital of Nanjing military region from January 2006 to December 2014, and 1374 healthy controls who were visited by sex and age (卤2 years) in non-tumor department of the hospital at the same time. Results in the case group, the pollution types of enterprises near the place of residence of lung cancer patients were waste gas pollution, wastewater pollution, dust pollution, many kinds of pollution, other pollution, family passive smoking. 10 years ago, cooking fuel was coal smoke type, cooking fuel was coal fume type in recent 10 years, indoor cooking oil fume quantity was very small, some, many, kitchen and bedroom were not separated, bedroom ventilation was general, the proportion of poor room ventilation was 10.20% and 3.2%, respectively. 2.2%, 2.6%, 1.5%, 46.5%, 40.2%, 11.6%, 54.7%, 23.8%, 4.5%, 2.9%, 18.5%, 3.3%, respectively, higher than 4.2%, 0.9%, 0.5%, 0.7%, 0.6%, 25.7%, 22.9%, 48.3%, 18.7%, 1.7%, 1.5%, respectively. 9.0%, 1.2% (all P 0.05); In the case group, patients with lung cancer used exhaust fan or lampblack machine, and the proportion of building type was 58.8%, 63.3% and 67.6%, respectively, which was lower than that of the control group (75.3%), 70.2% (86.8%) and 86.8% (P 0.05). After adjusting for gender, age, nationality, educational level, marital status, body mass index, smoking, occupational risk factor exposure history, tumor family history, lung disease history and other mixed factors, the results of multivariate unconditional logistic regression analysis showed that the pollution types of enterprises near the place of residence were exhaust gas, waste water, dust and many kinds of pollution, passive smoking in the family, and coal smoke type in cooking fuel 10 years ago. Indoor cooking fumes and poor ventilation in the room are the risk factors of lung cancer. Moderate heat of oil temperature and residential type are the protective factors of lung cancer. Conclusion Residential environment and indoor air pollution can increase the risk of lung cancer.
【作者单位】：福建医科大学公共卫生学院流行病与卫生统计学系;
【基金】：国家自然科学基金(81172766) 福建省卫生计生委青年科研项目(2014-1-37) 福建医科大学博士启动基金项目(201401)
【分类号】：R734.2

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