FOXM1在肺腺癌中的表达及与一线化疗疗效的关系
发布时间：2019-07-04 20:40
【摘要】：目的:肺癌是世界范围内致死率最高的肿瘤之一,叉头框转录因子M1(FOXM1)是调控细胞周期的转录因子,参与细胞增殖、分化的调控过程,同时还可介导细胞DN A的损伤修复和细胞凋亡过程。FOXM1表达上调与多种恶性肿瘤的发生、发展及预后密切相关。最新相关研究提示FOXM1可能与肿瘤药物耐药存在密切关系。本研究探讨非小细胞肺腺癌中叉头框转录因子M1(FOXM1)的表达水平及其与临床病理因素、一线化疗无进展生存期的关系,为FOXM1的表达与肺癌的治疗预后提供新的理论依据。方法:收集新疆医科大学附属肿瘤医院2012年~2015年期间非小细胞肺腺癌患者病理组织标本77例,运用免疫组化法检测肿瘤组织中的FOXM1表达水平,并结合临床病理特征及一线治疗无进展生存时间进行分析。结果:FOXM1的表达水平与肿瘤细胞的分化间存在相关性(P=0.02)。FOXM1表达水平与一线化疗治疗无进展生存时间及维持治疗时间具有相关性(P=0.001,P=0.003),FOXM1表达阳性患者的一线化疗治疗无进展生存时间要低于FOXM1表达阴性患者;结果显示FOXM1的阳性表达、吸烟及性别是影响预后的独立因素(P0.05)。结论:FO XM1表达水平与非小细胞肺腺癌一线治疗无进展生存时间密切相关,提示FOXM1表达水平与化疗治疗预后呈负相关。FOXM1阳性表达、吸烟及年龄这些因素可以作为NSCLC一线化疗治疗预后的独立预测指标
[Abstract]:Aim: lung cancer is one of the deadliest tumors in the world. Forked frame transcription factor M1 (FOXM1) is a transcription factor regulating cell cycle, which is involved in the regulation of cell proliferation and differentiation, and can also mediate the repair of cell DN A injury and apoptosis. The up-regulation of FOXM1 expression is closely related to the occurrence, development and prognosis of many kinds of malignant tumors. Recent studies suggest that FOXM1 may be closely related to tumor drug resistance. The purpose of this study was to investigate the expression of forked frame transcription factor M1 (FOXM1) in non-small cell lung adenocarcinoma and its relationship with clinicopathological factors and progression-free survival time of first-line chemotherapy, so as to provide a new theoretical basis for the expression of FOXM1 and the treatment and prognosis of lung cancer. Methods: the pathological specimens of 77 patients with non-small cell lung cancer from 2012 to 2015 were collected. The expression of FOXM1 in tumor tissues was detected by immunohistochemistry, and the clinicopathological features and the survival time of first-line treatment were analyzed. Results: there was a correlation between the expression level of FOXM1 and the differentiation of tumor cells (P 鈮，
本文编号：2510217
[Abstract]:Aim: lung cancer is one of the deadliest tumors in the world. Forked frame transcription factor M1 (FOXM1) is a transcription factor regulating cell cycle, which is involved in the regulation of cell proliferation and differentiation, and can also mediate the repair of cell DN A injury and apoptosis. The up-regulation of FOXM1 expression is closely related to the occurrence, development and prognosis of many kinds of malignant tumors. Recent studies suggest that FOXM1 may be closely related to tumor drug resistance. The purpose of this study was to investigate the expression of forked frame transcription factor M1 (FOXM1) in non-small cell lung adenocarcinoma and its relationship with clinicopathological factors and progression-free survival time of first-line chemotherapy, so as to provide a new theoretical basis for the expression of FOXM1 and the treatment and prognosis of lung cancer. Methods: the pathological specimens of 77 patients with non-small cell lung cancer from 2012 to 2015 were collected. The expression of FOXM1 in tumor tissues was detected by immunohistochemistry, and the clinicopathological features and the survival time of first-line treatment were analyzed. Results: there was a correlation between the expression level of FOXM1 and the differentiation of tumor cells (P 鈮，
本文编号：2510217
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