PCT、Activin-A等生物学指标在急性白血病患者化疗后粒细胞缺乏期感染中的诊断价值

发布时间：2019-08-10 12:28

【摘要】：目的探讨PCT、Activin-A等生物学指标在急性白血病患者化疗后粒细胞缺乏期感染中的诊断价值。方法自2013年1月-2016年1月,前瞻性收集急性白血病化疗后粒细胞缺乏患者112例,根据患者粒细胞缺乏期是否发生感染将其分为感染组64例和非感染组48例,比较两组患者血清不同生物学指标降钙素原(PCT)、C-反应蛋白(CRP)、淀粉样蛋白A(SAA)、Activin-A和中性粒细胞(NE)差异,并分析其在诊断患者感染中的临床价值。结果感染组患者PCT、CRP水平分别为(2.36±1.12)ng/ml、(41.39±20.52)mg/L,显著高于非感染组(0.28±0.16)ng/ml、(6.52±2.96)mg/L,差异有统计学意义(P0.05);感染组患者SAA、Activin-A水平分别为(274.00±112.66)mg/L、(0.45±0.20)ng/ml,明显高于非感染组(77.46±25.57)mg/L、(0.22±0.07)ng/ml,差异有统计学意义(P0.05);两组患者NE水平比较差异无统计学意义;PCT、CRP、SAA、Activin-A和NE等在预测患者感染中的曲线下面积分别为0.937、0.859、0.893、0.830和0.573;单因素和多因素logistic回归分析显示,PCT、CRP、SAA和Activin-A水平升高是患者感染的危险因素(P0.05)。结论 PCT、CRP、SAA和Activin-A在急性白血病化疗后粒细胞缺乏期均具有良好的应用价值。
[Abstract]:Objective to investigate the diagnostic value of PCT,Activin-A and other biological indexes in granulocyte deficiency infection in patients with acute leukemia after chemotherapy. Methods from January 2013 to January 2016, 112 patients with granulocytosis after chemotherapy were collected and divided into infection group (n = 64) and non-infection group (n = 48) according to whether the patients were infected during granulocyte deficiency. The differences of serum calmodulin (PCT), C-reactive protein (CRP), amyloprotein A (SAA), Activin-A and neutrophil (NE) between the two groups were compared. The clinical value of it in the diagnosis of infection was analyzed. Results the level of PCT,CRP in the infection group was (2.36 卤1.12) ng/ml, (41.39 卤20.52) mg/L, which was significantly higher than that in the non-infection group (0.28 卤0.16) ng/ml, (6.52 卤2.96) mg/L, (P 0.05). The level of SAA,Activin-A in infection group was (274.00 卤112.66) mg/L, (0.45 卤0.20) ng/ml, which was significantly higher than that in non-infection group (77.46 卤25.57) mg/L, (0.22 卤0.07) ng/ml, (P 0.05), but there was no significant difference in NE level between the two groups. The areas under the curve of PCT,CRP,SAA,Activin-A and NE in predicting infection were 0.937, 0.859, 0.893, 0.830 and 0.573, respectively. Univariate and multivariate logistic regression analysis showed that the increased levels of PCT,CRP,SAA and Activin-A were the risk factors for infection (P 0.05). Conclusion PCT,CRP,SAA and Activin-A have good application value in granulocyte deficiency after chemotherapy in acute leukemia.
【作者单位】：金华市中心医院血液科;
【基金】：浙江省医药卫生一般研究计划基金资助项目(2016KYA016)
【分类号】：R733.71

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