通窍止涕汤对肺脾虚寒型过敏性鼻炎的临床疗效观察

发布时间：2017-12-27 18:38

本文关键词：通窍止涕汤对肺脾虚寒型过敏性鼻炎的临床疗效观察　出处：《山西中医学院》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察通窍止涕汤对肺脾虚寒型过敏性鼻炎的临床治疗效果,探索其作用机理,并为进一步临床推广提供依据。方法:本试验共纳入80例患者,符合西医持续性过敏性鼻炎诊断标准,同时符合中医鼻鼽(肺脾虚寒型)辨证标准,并随机将其分为两组,每组各40例,治疗组予以通窍止涕汤免煎颗粒剂口服治疗,对照组予以西替利嗪片口服治疗。观察治疗前、治疗后2周、4周主要症状、体征、次要症状评分等数据变化。结果:1.总体疗效观察:治疗2周后:治疗组显效8例、有效21例、无效11例,总有效率为72.5%;对照组显效6例、有效23例、无效10例,总有效率为74.36%;治疗2周后,治疗组总有效率较对照组稍低,统计分析两组疗效差异无统计学意义(P0.05)。治疗4周后:治疗组显效19例、有效15例、无效6例,总有效率为85%;对照组显效17例、有效13例、无效9例,总有效率为76.92%;治疗4周后治疗组的总有效率高于对照组,统计分析两组疗效差异无统计学意义(P0.05)。2.主要症状观察:治疗2周后与治疗前相比较:两组均可改善流鼻涕、打喷嚏、鼻塞以及鼻痒等症状,两组组内相比较,经统计分析认为治疗前后差异均有统计学意义(P0.05);两组组间相比较,对主要症状改善无统计学意义(P0.05)。治疗4周后与治疗前相比较:两组均可改善流鼻涕、打喷嚏、鼻塞以及鼻痒等症状,两组组内分析比较,认为治疗前后差异均有统计学意义(P0.05);两组组间相比较,治疗组对改善打喷嚏症状较对照组更为显著,且有统计学意义(P0.05)。3.体征观察:治疗2周及4周后,两组组内比较,两组均可改善鼻甲肿大,治疗前后比较差异有统计学意义(P0.05);两组组间相比,对鼻甲肿大改善疗效相当,差异无统计学意义(P0.05)。4.次要症状观察:治疗2周后与治疗前比较:两组组内比较,治疗组对畏寒、食少证候显著改善,差异有统计学意义(P0.05),对照组对四项证候均无明显改善,无统计学意义(P0.05);两组组间相比,治疗组对畏寒、食少、便溏、背凉四项证候改善率均高于对照组,其中治疗组对畏寒、食少两项指标改善较对照组显著,差异有统计学意义(P0.05)。治疗4周后与治疗前比较:两组组内比较,治疗组对畏寒、食少、便溏、背凉四项证候均显著改善,治疗前后对比差异有显著统计学意义(P0.01),对照组对四项证候改善均不明显,治疗前后对比差异无统计学意义(P0.05)。两组组间比较,治疗组对四项证候的改善率均高于对照组,其中治疗组对畏寒、食少、便溏、背凉四项指标改善较对照组相比,差异均有显著统计学意义(P0.01)。结论:通窍止涕汤对肺脾虚寒型过敏性鼻炎临床疗效确切,其优势在于从根本上改善肺脾虚寒的体质,从而达到治疗疾病的目的,并且能够提高患者的生活质量,值得进一步推广。
[Abstract]:Objective: To observe the clinical effect of the treatment of nasal check Tongqiao Decoction on lung spleen deficiency cold type of allergic rhinitis, and explore its mechanism of action, and provide the basis for the further clinical application. Methods: This study included 80 patients with persistent allergic rhinitis with the western medicine diagnosis standard, at the same time with the traditional Chinese medicine allergic rhinitis (lung deficiency and cold syndrome), and randomly divided into two groups, 40 cases in each group. The treatment group was given Tongqiao Decoction stopping tears free Decoction oral treatment, the control group to cetirizine oral treatment. The changes of the main symptoms, signs and scores of secondary symptoms were observed before and after treatment, 2 and 4 weeks after treatment. Results: the overall curative effect observation of 1.: after 2 weeks of treatment: the treatment group 8 cases, 21 cases were effective, 11 cases ineffective, the total efficiency of 72.5%; control group, 6 cases markedly effective in 23 cases, 10 cases were invalid, the total effective rate was 74.36%; after 2 weeks of treatment, the total effective rate of treatment group compared with the control group slightly lower, statistical analysis of the efficacy of the two groups were not statistically significant (P0.05). After 4 weeks of treatment: the treatment group 19 cases, 15 cases were effective, 6 cases ineffective, the total efficiency of 85%; control group 17 cases, 13 cases were effective, 9 cases ineffective, the total effective rate was 76.92%; after 4 weeks of treatment, the total efficiency of the treatment group than the control group, the statistical analysis of the differences between the two groups the effect of no statistical significance (P0.05). Observe the 2. main symptoms: after 2 weeks of treatment compared with before treatment, the two groups can improve a runny nose, sneezing, nasal congestion, nasal itching and other symptoms in the two groups compared by statistic analysis before and after treatment were significantly different (P0.05); two groups were compared, the main symptoms no statistical significance (P0.05). After 4 weeks of treatment compared with before treatment, the two groups can improve a runny nose, sneezing, nasal congestion, nasal itching and other symptoms, compared in the two groups before and after treatment, that the differences were statistically significant (P0.05); two groups were compared, the treatment group to improve the symptoms of sneezing is more than that of the control group obviously, and there was statistical significance (P0.05). 3. signs observation: after 2 weeks and 4 weeks, the two groups could improve concha enlargement compared with those in the two groups. The difference between the two groups was statistically significant (P0.05). Compared with the two groups, there was no significant difference in the treatment of concha enlargement, and the difference was not statistically significant (P0.05). Observation of 4. secondary symptoms: after 2 weeks of treatment compared with before treatment, the two groups, treatment group of chills, eat less symptoms improved significantly, the difference was statistically significant (P0.05), the control group of four syndromes were not significantly improved, no statistical significance (P0.05) between the two groups were compared; the treatment group, chills, eat less, loose stools, back four cold syndrome improvement rate were higher than the control group, the treatment group of chills, eat less two indicators improved significantly compared with the control group, the difference was statistically significant (P0.05). After 4 weeks of treatment compared with before treatment: comparison of two groups, treatment group of chills, eat less, loose stools, cool back four syndromes were significantly improved, there was significant difference between before and after treatment (P0.01), the control group of four syndromes were not significantly improved, compared to no significant difference before and after treatment (P0.05). Between the two groups, the improvement of the four syndromes in treatment group were higher than that of control group, the treatment group of chills, eat less, loose stools, cool back four indicators improved compared with those in the control group, the difference was statistically significant (P0.01). Conclusion: the clinical curative effect of Tongqiao Decoction on stopping tears lung deficiency and cold of allergic rhinitis is effective, its advantage is to fundamentally improve the lung and spleen deficiency constitution, so as to achieve the purpose of treating disease, and can improve the quality of life of patients, is worthy of further promotion.
【学位授予单位】：山西中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R276.1

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