活血化瘀通络方治疗早期激素性股骨头坏死的临床研究

发布时间：2017-12-27 19:12

本文关键词：活血化瘀通络方治疗早期激素性股骨头坏死的临床研究　出处：《中药药理与临床》2017年04期 　论文类型：期刊论文

【摘要】：目的:研究活血化瘀通络方治疗早期激素性股骨头坏死的临床价值。方法:选取2015年3月至2017年4月我院收治的早期激素性股骨头坏死患者90例为研究对象,采用随机数表法分为观察组、对照组各45例,均于内固定术后2周内进行旋股内、外侧动脉介入术,术后对照组行常规治疗,观察组加服活血化瘀通络方,比较两组治疗有效率及治疗前后血清骨形成蛋白2(BMP2)、骨钙素(BGP)、转化生长因子-β1(TGF-β1)、内皮素(ET)水平,分析两组血浆黏度(ηp)、红细胞压积(HCT)、红细胞沉降率(ESR)等血液流变学指标,采用视觉模拟评分法(VAS)、Harris髋关节功能评分表评价两组疼痛度、关节功能,同时记录不良反应。结果:观察组治疗有效率88.89%,明显高于对照组71.11%;观察组治疗后血清BMP2(23.10±1.54)μg/L、BGP(38.20±1.11)pg/ml、TGF-β1(31.29±1.35)pg/ml均明显高于对照组,而ET水平(50.28±1.10)pg/ml明显低于对照组;治疗后观察组血ηp(1.02±0.21)mP a·s、HCT(25.10±1.24)%、ESR(12.19±0.14)mm/h明显低于对照组;治疗后观察组VAS评分(1.23±0.14)分明显低于对照组,Harris评分(89.45±1.13)分明显高于对照组;两组不良反应发生率11.11%、8.89%比较无显著差异。结论:活血化瘀通络方可有效治疗早期激素性股骨头坏死,改善其骨代谢及血液流变学指标,降低疼痛度,促进机体关节功能恢复,同时安全性好,值得在临床推广应用。
[Abstract]:Objective: To study the clinical value of Huoxue Huayu Tongluo Recipe (Huoxue Huayu Tongluo recipe) in the treatment of early hormone necrosis of the femoral head. Methods: from March 2015 to April 2017 in our hospital, the avascular necrosis of the femoral head in 90 patients as the research object, divided into observation group and control group with 45 cases in each group randomly, both in internal fixation within 2 weeks after the lateral and medial femoral circumflex artery intervention after surgery, the control group received routine treatment, the observation group with oral Huoxue Huayu Tongluo recipe, compared two groups of the effective rate of the treatment and treatment of serum bone morphogenetic protein 2 (BMP2) and Osteocalcin (BGP), transforming growth factor beta 1 (TGF- beta 1) and endothelin (ET) level, the analysis of plasma viscosity of two groups (N P), red blood cell hematocrit (HCT), erythrocyte sedimentation rate (ESR) and blood rheology indicators, using the visual analogue scale (VAS), Harris hip score evaluation of two groups of pain, joint function, and record adverse reactions. Results: in the observation group, the total effective rate was 88.89%, 71.11% higher than the control group; the observation group after treatment serum BMP2 (23.10 + 1.54) g/L, BGP (38.20 + 1.11) pg/ml, TGF- beta 1 (31.29 + 1.35) pg/ml were significantly higher than the control group, while the level of ET (50.28 + 1.10) pg/ml was significantly lower than the control group after treatment; the observation group of blood p (1.02 + 0.21) mP a - s, HCT (25.10 + 1.24)%, ESR (12.19 + 0.14) mm/h was significantly lower than the control group; after treatment, the VAS score of the observation group (1.23 + 0.14) was significantly lower than the control group, Harris score (89.45 + 1.13) points significantly higher than the control group; the adverse effects of the two groups, there is no significant difference between 8.89% and 11.11%. Conclusion: Huoxue Huayu Tongluo Decoction can effectively treat steroid induced avascular necrosis of the femoral head, improve its bone metabolism and hemorheology index, reduce pain and promote joint function recovery. Meanwhile, it has good safety and is worthy of clinical application.
【作者单位】：海南医学院第一附属医院;
【分类号】：R274.9
【正文快照】： 内、外侧动脉介入术,术后对照组行常规治疗,观察组加服活血化瘀通络方,比较两组治疗有效率及治疗前后血清骨形成蛋白2(BMP2)、骨钙素(BGP)、转化生长因子-β1(TGF-β1)、内皮素(ET)水平,分析两组血浆黏度(ηp)、红细胞压积(HCT)、红细胞沉降率(ESR)等血液流变学指标,采用视觉

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