肺康宁合剂对慢性阻塞性肺疾病肺动脉高压患者内皮素和D-二聚体的影响

发布时间：2017-12-27 20:00

本文关键词：肺康宁合剂对慢性阻塞性肺疾病肺动脉高压患者内皮素和D-二聚体的影响　出处：《中华中医药学刊》2017年01期 　论文类型：期刊论文

【摘要】：目的:探讨肺康宁合剂治疗慢性阻塞性肺疾病肺动脉高压患者临床疗效,并观察其对内皮素-1(ET-1)、D-二聚体的影响。方法:回顾性分析医院52例慢性阻塞性肺疾病肺动脉高压患者临床诊治情况,其中以常规治疗者为对照组(21例);于常规治疗基础上采用肺康宁合剂治疗者为治疗组(31例)。检测两组患者治疗前、后ET-1、D-二聚体及肺动脉压变化,统计两组临床疗效及临床症状、体征(咳嗽、喘息、咳痰及哮鸣音)积分变化,观察治疗期间不良反应。结果:治疗后,两组患者ET-1、D-二聚体及肺动脉压水平均较治疗前显著下降,治疗组各项指标下降程度明显优于对照组,P0.05;两组患者治疗后咳嗽、喘息、咳痰及哮鸣音积分较治疗前明显下降,治疗组各项症状、体征积分下降程度优于对照组,P0.05。治疗组治疗总有效率90.32%,明显高于对照组57.14%,P0.05;治疗期间未见严重性不良反应。结论:采用肺康宁合剂治疗慢性阻塞性肺疾病肺动脉高压可显著改善其肺动脉高压及临床各项症状、体征,提高临床疗效且具有一定安全性,然该药物作用机制可能与其改善患者血管内皮功能及高凝状态有一定关系。
[Abstract]:Objective: To investigate the clinical efficacy of Corelle mixture in the treatment of chronic obstructive pulmonary disease with pulmonary hypertension and observe its effect on endothelin -1 (ET-1) and D- two dimer. Methods: the clinical diagnosis and treatment of 52 patients with chronic obstructive pulmonary disease with pulmonary hypertension were retrospectively analyzed. Among them, the conventional treatment group was 21 cases (control group). On the basis of routine treatment, the treatment group was treated with lung Corelle mixture (31 cases). The changes of ET-1 and D- two dimers and pulmonary arterial pressure in two groups before and after treatment were detected. The clinical efficacy and clinical symptoms, signs (cough, wheezing, expectoration and wheezing) integral changes of two groups were statistically analyzed, and adverse reactions during treatment were observed. Results: after treatment, two groups of patients with ET-1, two D- dimer and pulmonary artery pressure levels were significantly lower than before treatment, the index of the treatment group decreased significantly than the control group, P0.05; cough, wheezing, cough and wheeze score was significantly decreased than that before treatment in two groups of patients after treatment, the symptoms of the treatment group and signs integral decreased than the control group, P0.05. The total effective rate of treatment in the treatment group was 90.32%, which was significantly higher than that of the control group (57.14%), P0.05, and no severe adverse reaction was found during the treatment. Conclusion: the lung Corelle mixture in the treatment of chronic obstructive pulmonary disease and pulmonary arterial hypertension can significantly improve the pulmonary arterial pressure and clinical symptoms and signs, improve the clinical curative effect and has certain safety, so the drug mechanism may be related to the improvement of vascular endothelial function in patients with hypercoagulable state and have a certain relationship.
【作者单位】：杭州市第三人民医院呼吸内科;
【分类号】：R259
【正文快照】： 慢性阻塞性肺疾病主要是一种气流受限呈进行性且以不完全可逆的气流受限为特征,该疾病与肺对气体等异常炎症相关的疾病状态[1]。随着社会环境、气候地不断变化,该疾病发病率呈逐年上升趋势,给人类生命健康造成一定威胁。慢性阻塞性肺疾病可使患者通气机理紊乱和肺泡换气障碍,

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