艾炷灸抗哮喘小鼠气道炎症机制研究

发布时间：2017-12-27 20:08

本文关键词：艾炷灸抗哮喘小鼠气道炎症机制研究　出处：《中国中医基础医学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的:通过观察艾炷灸对哮喘模型小鼠血清超氧化物歧化酶(SOD)活性、一氧化氮(NO)和丙二醛(MDA)水平的影响,探讨其抗哮喘气道炎症的作用机制。方法:昆明种小鼠32只按随机数字表法分为空白组、哮喘模型组、艾炷灸治疗组、硫酸特布他林(Terbutaline Sulfate,TS)阳性组,空白组用生理盐水腹腔注射和雾化吸入,其余各组采用卵清蛋白(OVA)腹腔注射致敏和雾化激发哮喘,哮喘模型制作成功后,分别利用生理盐水雾化、TS雾化液、艾炷灸进行治疗,2周后测小鼠血清的MDA、SOD、NO值,观察对比各组肺组织形态。结果:与空白组比较,哮喘模型组小鼠血清MDA、NO水平显著增高;与哮喘模型组比较,TS阳性组、艾炷灸治疗组的MDA水平显著降低;与空白组比较,哮喘模型组小鼠血清SOD水平显著降低;与哮喘模型组比较,TS阳性组、艾炷灸治疗组的SOD水平显著增加。结论:艾炷灸能明显抑制哮喘小鼠气道炎症,其机制可能与其降低机体NO、MDA水平,增强SOD的活力有关。
[Abstract]:Objective: through the observation of moxa cone moxibustion on asthma model in mice serum superoxide dismutase (SOD) activity and nitric oxide (NO) and malondialdehyde (MDA) levels, and investigate its mechanism of anti asthmatic airway inflammation. Methods: 32 Kunming mice were randomly divided into control group, asthma model group, moxibustion treatment group, terbutaline sulfate (Terbutaline, Sulfate, TS) positive group and blank group with saline intraperitoneal injection and aerosol inhalation, the other groups were given intraperitoneal injection of ovalbumin (OVA) sensitization and atomization stimulate asthma, asthma model was established successfully, using saline atomization, atomization, TS moxibustion treatment, measured 2 weeks after the mice serum MDA, SOD, NO, lung morphology observation. Results: compared with the control group, asthma model group serum MDA, NO levels increased significantly; compared with the asthma model group, TS positive group, moxibustion treatment group MDA were significantly reduced; compared with the control group, asthma model group serum SOD levels were significantly reduced; compared with the asthma model group, positive group, TS the Moxa Moxibustion treatment group the level of SOD was significantly increased. Conclusion: moxibustion can inhibit airway inflammation in asthmatic mice, the mechanism may be related to decrease the NO and MDA levels, enhanced SOD activity.
【作者单位】：崇左市人民医院中医康复科;
【分类号】：R245.81
【正文快照】： 中医认为,哮喘是由于寒邪伤肺、肺肾两虚等导致痰气交阻、阻塞气道、肺气升降不利进而出现呼吸困难、气息喘促[1]。艾灸是利用灸火温热性给予人体温热刺激,渗透入经络腧穴,是治疗和防治疾病的一种方法,其温经散寒、活血通络、扶阳固脱是中医学治疗哮喘的常用治疗方法。临床观

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