运用《伤寒论》火逆理论干预急性放射性直肠炎的临床研究

发布时间：2017-12-28 05:42

本文关键词：运用《伤寒论》火逆理论干预急性放射性直肠炎的临床研究　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的通过临床研究,结合《伤寒论》火逆理论,采用清热解毒,凉血滋阴法,观察口服清营汤加减与连栀矾制剂保留灌肠联合西药治疗急性放射性直肠炎是否比单用西药具有更好的临床疗效和安全性。方法采取随机对照的方式将成都肛肠专科医院研究的住院患者分为治疗组和对照组各20例。对照组给予西医基础治疗,治疗组在此基础之上加用口服清营汤加减联合连栀矾制剂保留灌肠治疗。治疗14天后观察2组的临床疗效。比较两组治疗前后临床疗效、中医症状评分、肠镜检查直肠粘膜改变、大便隐血情况、KPS改变、总有效率及治疗的不良反应等。结果治疗组总有效率85.0%优于对照组总有效率70.0%,二者比较差异有统计学意义(P0.05)。治疗组治疗后优于治疗前的有：中医症状评分、直肠粘膜、KPS及大便隐血改善情况,比较差异有统计学意义(P0.05)。治疗组在少腹胀痛、里急后重、大便稀溏及失眠多梦症状上优于对照组(P0.05,P0.01),两组在改善大便隐血情况程度上两组并无明显差异。对照组治疗前后无明显差异的有：KPS和直肠粘膜变化。两组患者治疗前后均未出现明显不良反应。结论口服清营汤加减与连栀矾制剂保留灌肠联合西药治疗急性放射性直肠炎比单纯西药治疗总体疗效好,更值得临床广泛应用。
[Abstract]:Objective through clinical research, combined with the "Treatise on the" fire inverse theory, using Qingrejiedu, Liangxue nourishing Yin, Qingying Decoction and observation of oral preparation of alum retention enema and even Zhi western medicine in the treatment of acute radiation proctitis is better than single western medicine has better clinical efficacy and safety. Methods the hospitalized patients in the Chengdu anorectal specialist hospital were divided into 20 cases in the treatment group and the control group. The control group was given the basic treatment of Western medicine, the treatment group based on the use of oral Qingying Decoction Combined with Yinzhihuang preparation alum retention enema in the treatment of. The clinical efficacy of the 2 groups was observed after 14 days of treatment. Before and after treatment between the two groups of clinical curative effect, TCM symptom score, colonoscopy and rectal mucosa changes, fecal occult blood, KPS changes, the total efficiency of treatment and adverse reaction etc.. Results the total effective rate of the treatment group was 85% better than that of the control group, and the total effective rate was 70%. The difference between the two groups was statistically significant (P0.05). The treatment group after treatment than before treatment, TCM symptom score, rectal mucosa, KPS and fecal occult blood to improve the situation, the difference was statistically significant (P0.05). The treatment group in the lower abdomen pain, tenesmus, loose stool and insomnia symptoms than the control group (P0.05, P0.01), the two groups in the improvement of the situation of two fecal occult blood group had no obvious difference. In the control group, there were no significant differences before and after treatment: KPS and the changes in the rectal mucosa. There was no obvious adverse reaction before and after treatment in the two groups. Conclusion oral Qingying Decoction retention enema and even Zhi alum preparation combined with western medicine in the treatment of acute radiation proctitis than the pure western medicine treatment the overall effect is good, it is worth in clinical application.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R273

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