柴胡疏肝散加减对脑梗死后抑郁患者血清细胞因子影响及临床疗效研究

发布时间：2017-12-28 05:44

本文关键词：柴胡疏肝散加减对脑梗死后抑郁患者血清细胞因子影响及临床疗效研究　出处：《辽宁中医杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨柴胡疏肝散加减对脑梗死后抑郁患者血清细胞因子影响及临床疗效。方法:选取本院神经内科诊断及治疗的脑梗死后抑郁患者84例,按随机数字表法进行分组,对照组患者42例予以舍曲林治疗,研究组患者42例在对照组基础上予以柴胡疏肝散加减治疗,采血检测血清S100β及BDNF水平、血清细胞因子水平,记录生存状况评分,同时对比临床疗效及并发症。结果:对照组治疗有效率71.43%低于研究组治疗有效率90.48%,具有统计学意义(P0.05);与对照组比较,研究组患者治疗后血清S100β水平降低,血清BDNF水平升高,治疗后血清CRP、IL-6及TNF-α水平降低,治疗后HAMD、NIHSS及ADL评分降低,MMSE评分升高,具有统计学意义(P0.05);两组患者不良反应多为轻中度,患者能够耐受,对症处理后缓解。结论:柴胡疏肝散加减对脑梗死后抑郁患者疗效确切,降低血清细胞因子,值得推广。
[Abstract]:Objective: To investigate the effect of Chaihu Shugan powder on serum cytokine and its clinical effect in patients with depression after cerebral infarction. Methods: 84 patients with depression were selected for diagnosis and treatment of the neurology department of our hospital after cerebral infarction were divided into two groups randomly, 42 patients in the control group were treated with sertraline in the treatment of patients in the study group, 42 cases in the control group on the basis of ChaiHuShuGan powder treatment, blood serum S100 level, serum BDNF and beta cell cytokines and recorded the survival status score, and the clinical effect and complications of contrast. Results: in the control group the effective rate was 71.43% lower than the effective rate of treatment group 90.48%, with statistical significance (P0.05); compared with the control group, serum S100 of patients in the study group after treatment decreased serum level of BDNF after treatment, serum CRP, IL-6 and TNF- levels decreased, HAMD, NIHSS and ADL were lower after treatment, the MMSE score increased, with statistical significance (P0.05); the adverse reactions of the two groups were mild to moderate, the patients can tolerate the treatment. Conclusion: the addition and subtraction of Chaihu Shugan powder is effective for the patients with depression after cerebral infarction, and it is worth promoting to reduce the serum cytokines.
【作者单位】：天津中医药大学第二附属医院心理二诊室;秦皇岛市人民医院神经内科;
【分类号】：R277.7
【正文快照】： 脑梗死后抑郁是脑梗死后常见的并发症,其发生率达到20%~60%[1-2]。由于多数脑梗死患者存在神经功能障碍,语言交流不利,极易引起漏诊和误诊现象,对患者的康复及生存质量产生影响,并且增加患者死亡率[3]。因此采取及时、有效的治疗措施既能够提高梗死抑郁患者的预后及生活质量,

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