肾阳亏虚型抑郁症患者面部动态情绪识别的脑功能研究

发布时间：2017-12-31 02:00

本文关键词：肾阳亏虚型抑郁症患者面部动态情绪识别的脑功能研究　出处：《中华中医药杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:前期临床研究发现肾阳亏虚证是抑郁症重要证型之一,本研究旨在探讨肾阳亏虚型抑郁症患者情绪识别的神经机制,并尝试对中医"肾主恐"理论进行脑功能阐释。方法:用3.0T功能磁共振系统检测12例肾阳亏虚抑郁症患者及相匹配12名健康志愿者识别恐惧、愤怒、高兴、中性面部表情视频的脑功能变化,图像数据经过格式转化,用SPM8软件进行分析。结果:肾阳亏虚证患者在识别恐惧情绪没有活动增强脑区,而在左侧楔前叶、左侧颞上回、左侧内侧额上回、右侧缘上回、右侧顶上回、右侧三角部额下回活动降低;在识别愤怒情绪时,活动增强的脑区是左侧杏仁核、左侧楔前叶、双侧背外侧额上回、右侧脑岛、右侧缘上回、右侧内侧和旁扣带脑回、右侧顶上回,活动降低的脑区在左侧三角部额下回;对于高兴情绪,未有活动变化的脑区;对于中性情绪在左侧枕中回、双侧杏仁核、右侧颞上回活动增强,在左侧额中回活动降低。结论:通过分析肾阳亏虚证患者识别上述4种情绪后脑区功能,肾阳亏虚证抑郁症是因过度消耗从而导致情绪识别的障碍,且同时存在认知能力的下降;中医"肾主恐"理论体现在空间注意力、记忆、认知等抽象能力及竞争性活动相关脑功能降低。
[Abstract]:Objective: early clinical studies found that deficiency of kidney yang is one of the most important types of depression. This study aims to explore the neural mechanism of emotion recognition in depression patients with deficiency of kidney yang. Methods: 12 patients with depressive depression due to deficiency of kidney yang and 12 matched healthy volunteers were detected by using 3.0T functional magnetic resonance system to identify fear and anger. Happy, neutral facial expression video brain function changes, image data after format transformation, using SPM8 software to analyze. Results: kidney Yang deficiency syndrome patients in the identification of fear emotion did not enhance the brain area. In the left anterior cuneate lobe, left superior temporal gyrus, left medial superior frontal gyrus, right superior marginal gyrus, right superior parietal gyrus, right triangular inferior frontal gyrus activity decreased. In identifying anger, the areas with increased activity were left amygdala, left prewedge lobe, bilateral dorsolateral superior frontal gyrus, right cerebral island, right superior marginal gyrus, right medial and parietal cingulate gyrus, and right superior parietal gyrus. The area with decreased activity was located in the inferior frontal gyrus of the left triangle. For happy mood, no activity changes in the brain; For neutral emotions in the left occipital gyrus, bilateral amygdaloid nucleus, right superior temporal gyrus activity increased, in the left frontal middle gyrus activity decreased. Deficiency of kidney yang syndrome depression is due to excessive consumption resulting in emotional recognition obstacles, and at the same time there is a decline in cognitive ability; The theory of "kidney dominating fear" in traditional Chinese medicine is embodied in the reduction of spatial attention, memory, cognition and brain function associated with competitive activities.
【作者单位】：北京中医药大学;北京市丰台区中西医结合医院;北京中医药大学第三附属医院;
【基金】：国家自然科学基金项目(No.81573905)~~
【分类号】：R277.7
【正文快照】： 抑郁症是以显著而持久的心境低落、思维迟缓、认知功能损害、意志活动减退和躯体症状为主要特征的一类心境障碍[1]。2013年WHO统计抑郁症和恶劣心境者患病率达12.8%,并预测2020年抑郁症将成为全球第2位医疗疾患[2]。该病不仅使患者健康受到损害,生活质量下降,而且给家庭和社会

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