龙胆泻肝汤联合刺血疗法治疗老年带状疱疹后遗神经痛的临床疗效观察

发布时间：2017-12-31 02:07

本文关键词：龙胆泻肝汤联合刺血疗法治疗老年带状疱疹后遗神经痛的临床疗效观察　出处：《中华中医药学刊》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨龙胆泻肝汤联合刺血疗法治疗老年带状疱疹后遗神经痛的临床疗效。方法:选取研究对象64例老年带状疱疹后遗神经痛患者,随机分成两组,每组32例。对照组给予常规综合治疗,维生素B1+甲钴胺片+加巴喷丁胶囊,治疗组在此基础上再予龙胆泻肝汤联合刺血疗法治疗,连续治疗15 d。检测治疗前后外周血T淋巴细胞亚群及血清P物质水平,VAS、QOL评分,观察其临床疗效及安全性。结果:与治疗前比较,两组外周血CD_3~+、CD_4~+以及CD_4~+/CD_8~+明显升高(P0.05),CD_8~+明显降低(P0.05),血清P物质水平以及VAS评分显著降低(P0.01),QOL评分显著升高(P0.01);与对照组比较,治疗组外周血CD_4~+以及CD_4~+/CD_8~+较高(P0.05),CD_8~+较低(P0.05),血清P物质水平以及VAS评分较低(P0.01),QOL评分较高(P0.01),治疗有效率较高(P0.05)。结论:龙胆泻肝汤联合刺血疗法能显著减轻老年带状疱疹后遗神经痛患者的疼痛症状,提高生存质量,可能机制为调节T淋巴细胞亚群及降低血清P物质水平。
[Abstract]:Objective: to investigate the clinical effect of Longdan Xiegan decoction combined with blood pricking therapy on senile postherpetic neuralgia. Methods: 64 elderly patients with postherpetic herpes zoster neuralgia were randomly divided into two groups. 32 cases in each group. The control group was treated with routine comprehensive treatment, vitamin B1 methylcobalamin tablets plus bapentin capsule, and the treatment group was treated with Longdan Xiegan decoction combined with blood pricking therapy on this basis. After 15 days of continuous treatment, the peripheral blood T lymphocyte subsets and serum substance P level were measured and VAS-QOL scores were measured to observe the clinical efficacy and safety. Results: compared with before treatment. The levels of CD3 / CD8 in peripheral blood of both groups were significantly higher than those of CD3 / CD8 / CDS. Serum substance P level and VAS score decreased significantly (P 0.01) and QOL score increased significantly (P 0.01). Compared with the control group, the peripheral blood CD4 ~ and CD4 ~ / CD8 / CDT in the treatment group were higher than that in the control group (P0.05 ~ lower P0.05). The serum level of substance P and the VAS score were lower (P 0.01) and higher (P 0.01). Conclusion: Gentian Xiegan decoction combined with blood pricking therapy can significantly reduce the pain symptoms of the elderly patients with postherpetic neuralgia and improve the quality of life. The possible mechanism is to regulate T lymphocyte subsets and reduce the level of substance P in serum.
【作者单位】：金华市第五医院皮肤科;
【分类号】：R752.12
【正文快照】： 带状疱疹是嗜神经及水痘-带状疱疹病毒[1],感染引起的一种皮肤科常见的疾病。若未能及时给予治疗,可发展为带状疱疹后遗神经痛(postherpetic neuralgia,PHN),疼痛持续数月甚至数年之久。研究调查显示13.7%~19.5%的带状疱疹患者会发展成PHN[2],而长期剧烈疼痛也极易引起患者情

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