苁蓉颗粒治疗帕金森病非运动症状的临床研究

发布时间：2017-12-31 10:30

本文关键词：苁蓉颗粒治疗帕金森病非运动症状的临床研究　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：帕金森病(Parkinson's disease, PD)除具有明显的运动障碍症状外,还有相对比较隐秘的非运动症状。由于非运动症状往往贯穿于疾病全程,并且严重影响PD患者的生活质量,近年来逐渐进入研究学者的视野,而PD非运动症状的治疗更是成为研究热点。由于目前西药在治疗非运动症状方面疗效欠佳,有的药物甚至会加重部分非运动症状,而中医药对改善此类症状有一定疗效,前景广阔。苁蓉颗粒是导师在理论研究的基础上,结合多年治疗帕金森病的临床经验总结提炼出来的,临床初步观察,该药在治疗帕金森病非运动症状方面有一定疗效。为了进一步了解苁蓉颗粒治疗帕金森病的临床疗效,设立本课题,应用国际认可的帕金森病诊断标准、疗效判定标准及病情分级标准,观察苁蓉颗粒治疗帕金森病非运动症状的临床疗效及其延缓疾病进展的效果,奠定补益肾脏药物治疗帕金森病的理论和临床基础。方法：选取2014.12-2015.12期间就诊于南京中医药大学第三附属医院脑病科门诊及住院PD患者60例,采用随机分组的方式,分成治疗组和对照组两组(每组30例),治疗组(同时服用苁蓉颗粒及抗帕金森西药)、对照组(单服抗帕金森西药)。两组分别治疗3个月后进行疗效评价,对比治疗前后非运动症状量表(NMSS)评分、帕金森病生活质量问卷-39(PDQ-39)评分、帕金森病统一评定量表(UPDRS)评分、Hoehn Yahr (H-Y)分级量表进行疗效评估。所有数据均以SPSS 17.0统计软件进行统计学处理。结果：治疗前后,对比两组患者NMSS量表评分,统计有效率得出,治疗组有效率为66.67%,对照组有效率为10.00%,两组非运动症状疗效比较差异明显,具有统计学意义(P0.05)；治疗组非运动症状的改善程度明显优于对照组,证实苁蓉颗粒能够改善PD患者的非运动症状。在生活质量方面,治疗组患者PDQ-39评分平均下降8.9分,而对照组评分平均下降0.3分,两组疗效比较具有统计学意义(P0.05),表明苁蓉颗粒能够显著改善PD患者的生活质量。在运动症状方面,治疗组在治疗前后UPDRS评分差异无统计学意义,表明苁蓉颗粒对运动症状的改善无益；虽然治疗组UPDRS评分有一定程度下降,但与对照组相比差异并无统计学意义(P0.05),说明加服苁蓉颗粒对运动症状的治疗效果与单纯服用西药相比并无明显优势。
[Abstract]:Objective: Parkinsonian disease (PDD) has obvious dyskinesia. There are relatively secret non-motor symptoms. Because non-motor symptoms often run through the whole process of the disease, and seriously affect the quality of life of PD patients, in recent years gradually into the field of vision of researchers. However, the treatment of PD non-motor symptoms has become a research hotspot. Because of the poor efficacy of western medicine in the treatment of non-motor symptoms, some drugs may even aggravate some non-motor symptoms. Cistanche granule is based on theoretical research, combined with many years of clinical experience in the treatment of Parkinson's disease, clinical preliminary observation. In order to further understand the clinical efficacy of Cistanche granulata in the treatment of Parkinson's disease, the subject was established and the internationally recognized diagnostic criteria for Parkinson's disease were applied. To observe the clinical efficacy of Cistanche granule in the treatment of non-exercise symptoms of Parkinson's disease and the effect of delaying the progress of the disease. To establish the theoretical and clinical basis of tonifying kidney drugs for Parkinson's disease. Methods:. 60 PD patients were selected from the Department of Encephalopathy in the third affiliated Hospital of Nanjing University of traditional Chinese Medicine from April 12 to December 2015. The patients were randomly divided into two groups: the treatment group (30 cases) and the control group (30 cases in each group). The treatment group (taking Cistanche granule and antiParkinson drugs). In the control group, the therapeutic effect was evaluated after 3 months of treatment, and the scores of NMSSs were compared before and after treatment. Parkinson's disease quality of life questionnaire -39 (PDQ-39) score, Parkinson's disease unified rating scale (UPDRS) score. The curative effect was evaluated by Hoehn Yahr scale. All the data were statistically processed by SPSS 17.0 statistical software. Results: before and after treatment. Compared with the NMSS score of the two groups, the effective rate of the treatment group was 66.677.The effective rate of the control group was 10.00. There was a significant difference between the two groups in the efficacy of non-exercise symptoms. It has statistical significance (P0.05). The improvement of non-motor symptoms in the treatment group was significantly better than that in the control group, which confirmed that Cistanche granule could improve the non-exercise symptoms of PD patients and the quality of life. The PDQ-39 score of the patients in the treatment group decreased by 8.9 points on average, while that in the control group decreased by 0.3 points on average. There was significant difference between the two groups (P 0.05). Congrong granule can significantly improve the quality of life of PD patients. In terms of motor symptoms, there is no significant difference in UPDRS score before and after treatment in the treatment group. The results showed that Cistanche granule had no effect on the improvement of exercise symptoms. Although the UPDRS score of the treatment group decreased to some extent, there was no significant difference compared with the control group (P 0.05). It showed that the therapeutic effect of Cistanche granule on sports symptoms had no obvious advantage compared with western medicine alone.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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