清热化湿解毒法治疗溃疡性结肠炎大肠湿热证的临床观察

发布时间：2017-12-31 11:16

本文关键词：清热化湿解毒法治疗溃疡性结肠炎大肠湿热证的临床观察　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的:通过清热化湿解毒法对活动期溃疡性结肠炎大肠湿热证患者的治疗,观察清热化湿解毒法对此类患者的临床疗效。研究方法:选择2016年01月至2016年12月就诊于黑龙江中医药大学附属第一医院肝脾胃病科门诊并符合纳入标准的活动期溃疡性结肠炎大肠湿热证患者40例,予以谢晶日教授清热化湿解毒法的中药汤剂治疗,药物由黑龙江中医药大学附属第一医院中药局统一提供,每日2次,每次150ml,早、晚饭前30分钟温服,连续服用4周为一个疗程,观察患者治疗前后的临床疗效、中医证候及电子结肠镜下肠黏膜变化情况,并对结果进行统计学分析。结果:清热化湿解毒法治疗活动期溃疡性结肠炎大肠湿热证的临床总有效率为86.49%,肠黏膜病变的总有效率为83.78%,中医证候总有效率为89.19%。治疗后的中医证候总积分较治疗前有明显下降,且差异显著(P值＜0.01),具有统计学意义。在中医单项证候积分方面,治疗后患者腹泻、黏液脓血便、腹痛、里急后重、肛门灼热、身热不扬、口干口苦、溲赤的证候积分较治疗前均有明显降低,且差异具有显著统计学意义(P值＜0.01)。结论:1、清热化湿解毒法能够有效改善活动期UC患者大肠湿热证的中医证候表现。2、清热化湿解毒法能够有效改善活动期UC患者大肠湿热证的肠镜下黏膜病变情况。
[Abstract]:Objective: to treat the patients with active ulcerative colitis with damp-heat syndrome by clearing heat and removing dampness and detoxification. To observe the clinical effect of the method of clearing heat and removing dampness and detoxification on this kind of patients. From January 2016 to December 2016, 40 patients with active ulcerative colitis with large intestine dampness and heat syndrome were selected from the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. . Xiejingri professor Qingrehua detoxification of traditional Chinese medicine decoction treatment, drugs by Heilongjiang University of Chinese Medicine affiliated to the first Hospital of Chinese Medicine Bureau of unified, twice a day, each 150ml, early. Take warm clothes 30 minutes before dinner, continuously take for 4 weeks as a course of treatment, observe the clinical efficacy, TCM syndromes and changes of intestinal mucosa under electronic colonoscopy before and after treatment. Results: the total effective rate of the treatment of active ulcerative colitis with damp-heat of large intestine was 86.49%. The total effective rate of intestinal mucosal lesions was 83.78 and the total effective rate of TCM syndromes was 89.19.The total score of TCM syndromes after treatment was significantly lower than that before treatment, and the difference was significant (P < 0.01). There is statistical significance. In Chinese medicine single syndrome integral, after treatment of diarrhea, mucus pus stool, abdominal pain, severe after acute, anal burning, body heat does not spread, dry mouth bitter. The syndrome score of Deutzia was significantly lower than that before treatment, and the difference was statistically significant (P < 0.01). Conclusion: 1. The method of clearing away heat and removing dampness and detoxifying can effectively improve the TCM syndromes of large intestine dampness and heat syndrome of UC patients in active period. 2. The method of clearing away heat and removing dampness and detoxifying can effectively improve the pathological changes of mucosa under endoscopy in patients with active UC.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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