加味不换金正气散治疗腹泻型肠易激综合征寒湿蕴结证的疗效评价研究

发布时间：2018-01-01 12:16

本文关键词：加味不换金正气散治疗腹泻型肠易激综合征寒湿蕴结证的疗效评价研究　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：从理论研究及临床研究两方面探讨加味不换金正气散治疗腹泻型肠易激综合征(irritable bowel syndrome-Diarrhea,简称IBS-D)寒湿蕴结证的临床疗效,并探讨其治疗机制。方法：将符合纳入标准的60例患者采用随机对照法,分为治疗组和对照组各30例。治疗组患者服用加味不换金正气散,对照组患者服用双歧杆菌三联活菌胶囊(培菲康)治疗,疗程为4周,记录治疗前、2周后及4周后的症状评分。结果：治疗组能显著改善患者的临床症状,尤其在总症状积分以及受凉劳累后发作或加重、畏寒怕冷、食欲不振、肠鸣症状方面,其疗效优于对照组(P0.05或P0.01)。在改善腹痛或腹部不适、大便次数、大便性状方面两组疗效相当(P0.05)。中医证候疗效方面,治疗组和对照组临床治愈例数分别为3例和1例,显效例数分别是22例和11例,有效例数分别是4例和15例,无效例数分别是1例和3例。治疗组的愈显率和有效率分别是83.3%和96.7%,对照组愈显率和有效率分别为40%和90%。经等级资料非参数检验,P0.05,差异有统计学意义,说明治疗组中医证候疗效方面优于对照组。两组在治疗期间均未发现明显不良反应。结论：加味不换金正气散及培菲康均对IBS-D寒湿蕴结证有明显疗效,且中药加味不换金正气散的疗效优于口服培菲康,值得临床推广应用。
[Abstract]:Objective: to explore the treatment of diarrhea irritable bowel syndrome (IBS) with modified Buxiangjin Zhengqi Powder from two aspects of theoretical and clinical study. Irritable bowel syndrome-Diarrhea. The clinical effect of IBS-D on the syndrome of cold and dampness accumulation and its therapeutic mechanism were discussed. Methods: 60 patients who met the inclusion criteria were treated with randomized controlled method. Treatment group and control group 30 cases each. The treatment group patients were treated with modified not changing Jin Zhengqi powder, the control group patients were treated with Bifidobacterium triple viable capsule (Peifeikang), the course of treatment was 4 weeks, recorded before the treatment. Results: the clinical symptoms of the patients were significantly improved in the treatment group, especially in the total symptom score, attack or aggravation after cold and tiredness, fear of cold, loss of appetite and bowel pain. The curative effect is better than that of control group (P0.05 or P0.01). In improving abdominal pain or abdominal discomfort, defecation frequency, defecation character, the two groups have the same curative effect as P0.05. Chinese medicine syndromes curative effect. The clinical cases of treatment group and control group were 3 cases and 1 case, 22 cases and 11 cases of marked effect, 4 cases of effective cases and 15 cases of effective cases, respectively. The effective rate and effective rate of the treatment group were 83.3% and 96.7% respectively. The effect rate and effective rate of control group were 40% and 90, respectively. The difference was statistically significant by non-parametric test of grade data (P0.05). The treatment group is superior to the control group in the curative effect of TCM syndromes. No obvious adverse reactions were found in the two groups during the treatment. Conclusion: Jiawei not changing Jin Zhengqi Powder and Peifeikang have obvious curative effect on IBS-D cold and dampness accumulation syndrome. The curative effect of modified Chinese medicine without changing Jin Zhengqi powder is better than that of oral peeficam, so it is worth popularizing in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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