川芎嗪注射液对急性心肌梗死介入手术后抑制心室重塑方面的影响

发布时间：2018-01-01 12:22

本文关键词：川芎嗪注射液对急性心肌梗死介入手术后抑制心室重塑方面的影响　出处：《辽宁中医杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:观察针对于急性心肌梗死行介入手术后接受川芎嗪注射液治疗的患者,其心室功能指标的变化,探究川芎嗪注射液对患者心室重塑的影响。方法:将2015年1月—2016年12月在本院接受介入手术的98例急性心肌梗死患者,按照术后药物干预方法的不同分为对照组和治疗组,各49例。其中对照组接受抗凝、抗血小板、降脂等基础治疗方案,治疗组在对照组的基础上还接受川芎嗪注射液治疗,分别在治疗1周、4周、8周、12周时,检查记录两组患者的心室功能的各项指标值。结果:治疗组的LVEDV和LVESD和对照组相比均显著降低(P0.05),且治疗组的第1个月和第2个月的指标水平相比也有显著降低(P0.05),第3个月则趋于稳定。治疗后,治疗组的LVEF则有显著的增加,后趋于稳定。结论:川芎嗪注射液在急性心肌梗死患者的PCI围术期的干预治疗对术后患者心功能恢复有很好的促进作用,可减少心室重塑发生的概率,这为临床用药提供了重要参考。
[Abstract]:Objective: To observe the patients received ligustrazine injection treatment for acute myocardial infarction patients after surgical intervention, the change of ventricular function index, effects of Ligustrazine Injection on patients with ventricular remodeling. Methods: from January 2015 to December 2016 in our hospital 98 cases of patients with acute myocardial infarction interventional operation, according to the different methods of drug intervention after operation the control group and treatment group, 49 cases in each group. The control group received anticoagulation, antiplatelet, lipid-lowering therapy, treatment group received Ligustrazine Injection Treatment on the basis of the control group, respectively, in the treatment of 1 weeks, 4 weeks, 8 weeks, 12 weeks, check the indicators of patients in two groups were recorded the ventricular function values. Results: the treatment group LVEDV and LVESD compared with the control group decreased significantly (P0.05), first and second months, the index level and the treatment group were significantly lower than (P0.05), Third months are stable. After treatment, the treatment group LVEF were significantly increased, and then tended to be stable. Conclusion: ligustrazine injection operation period in patients with acute myocardial infarction in PCI intervention has a very good role in promoting the recovery of the patients with postoperative cardiac function, ventricular remodeling can reduce the probability of occurrence. This provides an important reference for clinical medication.

【作者单位】：石家庄市第一医院心内科;
【基金】：河北省卫生厅科研基金项目(ZL20140164)
【分类号】：R259
【正文快照】： 急性心肌梗死(acute myocardial infarction,AMI)是严重威胁人类健康的疾病,具有发病突然、高病死率的特点[1];经皮冠状动脉介入治疗术(percutaneouscoronary intervention,PCI)是目前治疗急性心肌梗死的主要手段[2]。但是作为有创操作,PCI手术后常常会有心脏相关的并发症出现

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