健脾祛湿法治疗儿童期亚急性湿疹的临床研究

发布时间：2018-01-01 12:23

本文关键词：健脾祛湿法治疗儿童期亚急性湿疹的临床研究　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本课题从中西医两方面对湿疹的认识进行概述与总结。并将导师自拟健脾祛湿经验方对儿童亚急性湿疹进行临床研究,客观评价健脾祛湿法在治疗儿童亚急性湿疹的疗效与优势。方法:收集来自江苏省中医院皮肤科自2016年04月-2017年02月的门诊患儿共80例,将患儿按随机原则分为健脾祛湿方药治疗组41例、西替利嗪滴剂对照组39例。方药由本院药房统一煎煮,每日2次,早晚饭后半小时各1袋;对照组予西替利嗪滴剂,每晚1次,饭后半小时温水调服。两组均联合长效抗菌材料洁悠神外用。4周为一个疗程。分别通过湿疹面积及严重度指数(Eczema Area and Severity Index,EASI)评分、瘙痒程度的直观模拟标尺(Visual Analogue Scale,VAS)评分、儿童皮肤病生活质量指数(Children,s Dermatology Life Quality Index,CDLQI)量表、疗程结束后随访复发情况来观察疗效。结果:健脾祛湿方药组4周后总有效率为60.98%,西替利嗪滴剂4周后总有效率为35.90%,相比总有效率差异性显著(P0.05);治疗组治疗前EASI分值7.38±1.58,治疗后EASI分值2.37± 1.48,对照组治疗前EASI分值7.34±1.43,治疗后EASI分值3.37±159,两组用药前相比分值相近,无统计学意义(P0.05),治疗后相比,西替利嗪滴剂组分值明显高于健脾祛湿方药组,二者有显著性差异(P0.05);治疗组治疗前瘙痒程度积分6.15±1.46,经治后降为2.90±1.09,对照组治疗前瘙痒程度积分6.13±1.28,治疗后降为3.87±1.66,两组用药前相比分值相近,无显著性差异(P0.05),经治后相比有显著性差异(P0.05);治疗组治疗前CDLQI评分11.66±2.71,治疗后CDLQI评分5.51±1.08,对照组治疗前CDLQI评分12.05±2.97,经治后CDLQI评分8.08±2.04,两组用药前相比分值相近,无显著性差异(P0.05),治疗后相比有显著性差异(P0.05)。结论:健脾祛湿方药加减治疗儿童亚急性期湿疹明显优于西药组对照,疗效显著,复发率低,具有临床探讨价值。
[Abstract]:Objective: to summarize and summarize the cognition of eczema from two aspects of traditional Chinese and western medicine, and to make a clinical study on children subacute eczema with self-made prescription of invigorating spleen and removing dampness. Objective to evaluate the curative effect and advantage of tonifying spleen and removing dampness in treating children with subacute eczema. Methods: from April 2016 to February 2017, 80 outpatients were collected from dermatology department of Jiangsu Provincial traditional Chinese Medicine Hospital. According to the random principle, the children were divided into two groups: the treatment group (n = 41) with tonifying spleen and removing dampness, and the control group (n = 39) with cetirizine. The control group was given cetirizine drops once a night. Take warm water for half an hour after meal. Both groups were treated with long-term antibacterial material Jieyoushen for a course of 4 weeks. Eczema area and severity index (. Eczema Area and Severity Index. EASI) score, visual Analogue scale scale score of itching degree and children's quality of life index. S Dermatology Life Quality index (CDLQI). Results: the total effective rate of invigorating spleen and removing dampness prescription group was 60.98 after 4 weeks, and that of cetirizine drops was 35.90% after 4 weeks. Compared with the total effective rate, the difference was significant (P 0.05). The EASI score was 7.38 卤1.58 before treatment and 2.37 卤1.48 after treatment in the treatment group and 7.34 卤1.43 before the treatment in the control group. After treatment, the score of EASI was 3.37 卤159.The scores of the two groups were similar before and after treatment, and there was no significant difference between the two groups (P 0.05). The score of cetirizine drop group was significantly higher than that of invigorating spleen and removing dampness prescription group, there was significant difference between the two groups (P 0.05). The score of pruritus before treatment was 6.15 卤1.46 in the treatment group, and decreased to 2.90 卤1.09 after treatment, while that in the control group was 6.13 卤1.28 before treatment. After treatment, it decreased to 3.87 卤1.66. The scores of the two groups before treatment were similar, there was no significant difference (P 0.05), and there was significant difference after treatment (P 0.05). The CDLQI score before treatment was 11.66 卤2.71 in the treatment group, the CDLQI score was 5.51 卤1.08 after treatment, and the CDLQI score before treatment in the control group was 12.05 卤2.97. After treatment, the CDLQI score was 8.08 卤2.04.The scores of the two groups were similar before treatment, but there was no significant difference between the two groups (P0.05). Conclusion: the addition and subtraction of tonifying spleen and removing dampness prescription in treating children with subacute eczema is better than that in western medicine group, the curative effect is significant, the recurrence rate is low, and it has clinical value.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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