循经取穴针刺对慢性稳定型心绞痛患者症状及血清CRP、BNP的影响研究

发布时间：2018-01-01 19:06

本文关键词：循经取穴针刺对慢性稳定型心绞痛患者症状及血清CRP、BNP的影响研究　出处：《成都中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的本研究以慢性稳定型心绞痛(Chronic Stable Angina Pectoris, CSAP)为研究对象,评价循经取穴与非循经取穴针刺治疗对心绞痛患者的临床症状及血清脑钠肽(Brain Natriuretic Peptide, BNP)和C-反应蛋白(C-Reactive Protein, CRP)水平的影响。方法本研究共纳入CSAP患者36例,随机分为A、B两组。两组均进行10次针刺治疗。A组取手厥阴心包经内关穴和手少阴心经通里穴,B组取手阳明大肠经阳溪穴和偏历穴。针刺治疗前后分别以心绞痛发作次数、加拿大心脏病学会(Canada Cardiology Ssociation, CCS)心绞痛程度分级和视觉模拟评分(Visual Analogue Scale,VAS)评价患者心绞痛症状的变化情况,采用酶联免疫吸附测定法(Enzyme Linked Immuno Sorbent Assay,ELISA)观察循经与非循经两种取穴方法针刺对患者血清BNP和CRP水平的影响。所有数据均采用SPSS17.0统计软件进行分析处理。结果1.所纳入的36例受试者均完成了本试验研究。2.两组受试者基线一致,具有可比性(p0.05)。3.两种取穴针刺方法对CSAP患者症状的影响(1)与针刺前相比,循经取穴针刺可显著降低CSAP患者的心绞痛发作次数及VAS评分,差异具有统计学意义(p0.05),非循经取穴针刺可改善CSAP患者VAS评分,差异有统计学意义(p0.05)。(2)两种取穴针刺方法对CCS心绞痛严重程度分级、发作次数改善值、程度分级改善值及VAS改善值无显著差异(p0.05)。4.两种取穴针刺方法对心绞痛患者血清CRP、BNP水平的影响两组针刺治疗对心绞痛患者血清CRP、BNP水平均无显著影响(p0.05)；两种针刺方法对心绞痛患者血清CRP、BNP水平影响无显著组间差异(p0.05)。结论1.循经取穴和非循经取穴两种方案均可降低心绞痛患者的VAS评分,循经取穴针刺还可以减少心绞痛患者的心绞痛发作次数。2.由于疗程较短,样本量少,两种取穴方案对心绞痛患者血清CRP、BNP水平均无明显影响。3.试验中无明显不良事件及心血管事件发生。
[Abstract]:Objective to study chronic Stable Angina Pectoris (CSAP) of chronic stable angina pectoris. Objective: to evaluate the clinical symptoms and brain Natriuretic Peptide of patients with angina pectoris treated with acupoints along meridian and non-meridian acupoints. Methods 36 patients with CSAP were randomly divided into three groups. Group B. both groups were treated with acupuncture for 10 times. Group A took out the points of pericardial meridian of Hand-Jueyin and Tongli of Hand-Shaoyin Meridian. Group B took hand Yangming large intestine meridian Yangxi and Bianli points. Before and after acupuncture treatment with angina pectoris attack times. Canada Cardiology Ssociation. The changes of angina pectoris symptoms were evaluated by visual Analogue scale scale score and visual analogue score (VAS) in patients with angina pectoris. Enzyme Linked Immuno Sorbent Assay were determined by enzyme-linked immunosorbent assay (Elisa). Elsa). To observe the effect of acupuncture on serum BNP and CRP levels of patients with acupoints taken along meridian and non-meridian meridians. All data were analyzed by SPSS17.0 statistical software. Results 1. 2. The baseline of the two groups was the same. The effect of two acupuncture methods on the symptoms of CSAP patients was compared with that before acupuncture. Acupuncture along the meridian can significantly reduce the frequency of angina pectoris attack and VAS score in patients with CSAP, the difference is statistically significant (P 0.05). Non-meridian acupoint acupuncture can improve the VAS score of patients with CSAP, the difference is statistically significant (P 0.05. 0. 0. 0. 2) the two acupuncture methods for CCS angina pectoris severity classification. There was no significant difference in the improvement value of attack frequency, degree grade and VAS. The two acupuncture methods were used to treat the serum CRP of patients with angina pectoris. The effect of BNP level on the serum CRP level of patients with angina pectoris was not significantly affected by acupuncture therapy in both groups (P 0.05). Two acupuncture methods were used to treat serum CRP in patients with angina pectoris. There was no significant difference in the level of BNP between the two groups. Conclusion 1. The VAS score of patients with angina pectoris can be decreased by both the acupoint extraction along the meridian and the non-meridian acupoints. 2. Acupuncture along the meridian can also reduce the number of angina pectoris attacks in patients with angina pectoris. 2. Because of the short course of treatment, the sample size is small, the two methods of acupoint extraction in patients with angina pectoris serum CRP. No significant adverse events or cardiovascular events occurred in the trial.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.1

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