中医药治疗糖尿病并发抑郁症随机对照临床试验的Meta分析

发布时间：2018-01-02 23:09

本文关键词：中医药治疗糖尿病并发抑郁症随机对照临床试验的Meta分析　出处：《中华中医药学刊》2017年08期 　论文类型：期刊论文

【摘要】：目的:研究分析中医药治疗糖尿病并发抑郁症的临床效果及各相关指标的变化。方法:通过检索2005—2016年相关期刊论文(CNKI),中国生物医学数据库(CBM),万方数据库,维普数据库(VIP)中国内公开发表的中医药治疗糖尿病并发抑郁症的随机对照试验(RCT),运用Rev Man 5.3软件对符合纳入标准的文献进行Meta分析,比较分析中医药疗法与单纯西医疗法治疗糖尿病并发抑郁症的临床效果,以及治疗后患者空腹血糖,汉密尔顿抑郁量表(HAMD)评分的变化。结果:经过逐步筛选,最终纳入12个随机对照试验,共836例糖尿病并发抑郁症患者,Meta分析结果显示与对照组相比,中医药治疗糖尿病并发抑郁症的总体疗效较好,差异具有统计学意义(P0.05),患者治疗后空腹血糖,HAMD评分均降低,差异具有统计学意义(P0.05)。结论:中医药治疗糖尿病并发抑郁症的疗效优于单纯西医治疗,在降低血糖、HAMD评分方面具有较好的疗效,因纳入文献样本有限以及文献质量不高,尚需大样本以及多中心随机对照双盲试验的高质量研究来加以验证。
[Abstract]:Objective: to study the clinical effect of traditional Chinese medicine (TCM) in the treatment of diabetes mellitus complicated with depression. Methods: to search the full text database of Chinese Journal from 2005 to 2016 (CNKI). Chinese Biomedical Database (CBM), Wanfang Database, Wiper Database (VIPs) A randomized controlled trial (RCTs) of traditional Chinese medicine (TCM) in the treatment of diabetes mellitus and depression was published in China. Using Rev Man 5.3 software to carry on Meta analysis to the literature that accord with the inclusion standard, compare and analyze the clinical effect of traditional Chinese medicine therapy and western medicine therapy in treating diabetes mellitus complicated with depression. The changes of fasting blood glucose and Hamilton Depression scale (Hamd) scores after treatment. Results: after gradual screening, 12 randomized controlled trials were conducted. A total of 836 patients with diabetes mellitus complicated with depression were analyzed by Meta-analysis. Compared with the control group, Chinese medicine has a better overall efficacy in the treatment of diabetes mellitus complicated with depression. The difference was statistically significant (P 0.05). The scores of fasting blood glucose and Hamd decreased after treatment. The difference was statistically significant (P 0.05). Conclusion: traditional Chinese medicine is superior to western medicine in the treatment of diabetes mellitus complicated with depression, and has a better effect in reducing the score of blood glucose and Hamd. Due to the limited number of literature samples and the low quality of the literature, high quality studies of large samples and multicenter randomized controlled double-blind trials are needed to verify them.
【作者单位】：湖南中医药大学;
【基金】：国家自然科学基金项目(81573956) 湖南省高校创新平台开放基金项目(14K069) 湖南省教育厅研究生创新项目(CX2016B364)
【分类号】：R259;R277.7
【正文快照】： Meta-Analysis of Randomized Controlled Trials of Traditional ChineseMedicine in Treatment of Diabetes Mellitus Complicated with DepressionCAO Wen,PENG Zhiyuan,RU Rong,WANG Qiwei,SU Liqing(Hunan University of Traditional Chinese Medicine,Changsha 410007,H

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