张氏百草伤膏改制凝胶剂结合超声电导透射治疗膝痹病的疗效观察

发布时间：2018-01-03 02:36

本文关键词：张氏百草伤膏改制凝胶剂结合超声电导透射治疗膝痹病的疗效观察　出处：《中华中医药杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:观察张氏百草伤膏改制凝胶剂结合超声电导透射治疗膝痹病(KOA)的临床疗效。方法:KOA患者240例,随机分为3组:试验组采用超声电导透射百草伤膏凝胶贴片治疗,阳性药物对照组采用超声电导透射双氯酚酸二乙胺凝胶片治疗,百草伤膏组采用传统黑膏药百草伤膏外贴治疗,分别对3组治疗前及治疗后1、2、4周VAS疼痛评分、WOMAC骨关节炎指数以及安全性进行比较。结果:3组治疗前后VAS评分、膝关节WAMAC评分比较,差异均有统计学意义(P0.05),其临床疗效显著。试验组与百草伤膏组治疗后各观察时间段WAMAC评分差异均有统计学意义(P0.05),表明百草伤膏凝胶剂在膝关节临床疗效方面优于百草伤膏。试验组较阳性药物对照组VAS评分、WOMAC评分在第4周显著降低(P0.05),表明试验组在临床疗效上维持时间更长。不良反应观察试验组有1例出现局部皮疹,阳性药物对照组5例,百草伤膏组22例,差异有统计学意义(P0.05),表明试验组具有更好的安全性。结论:与传统黑膏药比较,张氏百草伤膏凝胶剂结合超声电导透射治疗KOA在早、中期是一种临床疗效显著、药效持续时间更长、安全性更高的中药外用方法。
[Abstract]:Objective: to observe the clinical effect of Zhang's Bancao shangshang ointment modified gel combined with ultrasonic conductance transmission in the treatment of knee arthralgia (KOAA). Three groups were randomly divided into three groups: the experimental group was treated with ultrasonic conductance transmission baccalophen ointment gel patch, and the positive drug control group was treated with ultrasonic conductance transmission dichlorophenol acid diethylamine gel tablet. The treatment group was treated with the traditional black plaster Bricao shangshang ointment. The pain scores of VAS were evaluated before and after 1 ~ 2 weeks of treatment in 3 groups. WOMAC osteoarthritis index and safety were compared. Results there were significant differences in VAS score and knee joint WAMAC score before and after treatment in the three groups (P 0.05). The clinical efficacy was remarkable. The WAMAC scores of the experimental group and the BCSO group were significantly different after treatment (P0.05). The results showed that the clinical curative effect of Brichaoshang ointment was better than that of the control group. The VAS score and WOMAC score of the test group were significantly lower than those of the positive control group in the 4th week (P 0.05). The results showed that the clinical efficacy of the trial group was longer than that of the control group. There were 1 case of local rash in the adverse reaction observation group, 5 cases in the positive drug control group and 22 cases in the BCSO group. The difference was statistically significant (P 0.05), which indicated that the experimental group had better safety. Conclusion: compared with the traditional black plaster, the combination of Zhang's Broccoli paste and ultrasonic conductance transmission therapy is early in the treatment of KOA. Medium-term is a more effective, longer-lasting and more safe method for external use of traditional Chinese medicine.
【作者单位】：杭州市富阳中医骨伤医院;北京中美联医学科学研究院;
【基金】：浙江省中西医结合骨关节病研究重点科技创新团队项目(No.2011R50022-15) 浙江省中医药重点学科建设项目(No.2012-XK-D03)~~
【分类号】：R274.9
【正文快照】： 膝痹病,即膝关节骨性关节炎(knee osteoarthritis,KOA),是一种临床常见的由于关节软骨退行性变引起的以关节疼痛和功能障碍为主要临床表现的疾病。在老年化社会日益加重的今天,其发病率呈不断上升趋势。张氏百草伤膏为富阳中医骨伤医院传统外用制剂,治疗KOA疗效肯定,但亦存在

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