山楂柠檬晶对功能性便秘的随机对照临床疗效观察

发布时间：2018-01-03 03:15

本文关键词：山楂柠檬晶对功能性便秘的随机对照临床疗效观察　出处：《成都中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察和评价山楂柠檬晶治疗功能性便秘的临床疗效。旨在研发一种既能有效改善便秘症状,预防便秘病情加重,又更易被患者接受的新型的、安全的功能性食品,期待为功能性便秘的预防与治疗开辟一条新的途径。方法：将符合纳入标准的60例功能性便秘患者随机分为两组,实验组30例,对照组30例,实验组给予山楂柠檬晶,对照组给予安慰剂(贝因美乐护乳清蛋白营养米粉),观察患者试验前1周,试验后第1、2、4周便秘积分变化,并收集临床数据对其进行统计学分析和疗效评定。结果：山楂柠檬晶实验组临床总有效率为84.85%,安慰剂(贝因美乐护乳清蛋白营养米粉)对照组临床总有效率为9.68%,实验组显著优于对照组；两组症状总积分比较在试验自第二周后差异具有统计学差异,证明实验组功能性便秘患者临床症状在治疗第二周后有效改善；在临床观察过程中,发现山楂柠檬晶改善患者排便时间、粪便性状症状效果显著,改善排便费力程度、排便不尽感、纳食减少症状效果确切,试验后腹部胀满、疲倦乏力症状较试验前有一定减轻,但尚不明显,有待进一步研究论证；而试验过程并未发现山楂柠檬晶有改善排便频率、腹中疼痛症状的作用；两组在治疗期间,并未出现不良反应事件。结论：山楂柠檬晶作为功能性保健食品,在改善功能性便秘方面,总体疗效确切,安全无毒副作用,值得临床推广应用。
[Abstract]:Objective: to observe and evaluate the clinical efficacy of Hawthorn lemon crystal in the treatment of functional constipation. Safe functional food is expected to open up a new way for the prevention and treatment of functional constipation. Methods: 60 patients with functional constipation who met the inclusion criteria were randomly divided into two groups: the experimental group (n = 30). 30 cases in the control group were given Hawthorn lemon crystal in the experimental group and placebo was given in the control group. The constipation score of the patients was observed 1 week before the trial and 2 weeks after the trial. The clinical data were collected for statistical analysis and efficacy evaluation. Results: the total effective rate of Hawthorn lemon crystal experimental group was 84.85%. The total clinical effective rate of the control group was 9.68, which was significantly better than that of the control group. There was statistical difference in the total symptom score between the two groups after the second week, which proved that the clinical symptoms of the patients with functional constipation in the experimental group were effectively improved after the second week of treatment. In the course of clinical observation, it was found that Hawthorn lemon crystal improved the time of defecation, the effect of fecal symptom was remarkable, the improvement of defecation was laborious, the defecation was not sensitive, the effect of reducing symptoms by taking food was definite, and the abdomen was full after the experiment. The symptoms of fatigue and fatigue were alleviated to some extent than those before the experiment, but the symptoms were not obvious, which needed to be further studied and demonstrated. However, it was not found that Hawthorn lemon crystal could improve defecation frequency and abdominal pain symptoms. Conclusion: Hawthorn lemon crystal as a functional health food, in the improvement of functional constipation, the overall efficacy is accurate, safe and no side effects. It is worth popularizing and applying in clinic.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35

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