慢性乙型肝炎证候虚实分类与外周血淋巴细胞亚群的关系

发布时间：2018-01-03 08:44

本文关键词：慢性乙型肝炎证候虚实分类与外周血淋巴细胞亚群的关系　出处：《中国中医基础医学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:了解慢性乙型肝炎(CHB)患者中医证候虚实分类与外周血淋巴细胞亚群之间的关系。方法:将CHB患者进行证候虚证、实证及虚实夹杂证分类,并检测其外周血T、B细胞及自然杀伤(NK)细胞亚群,并对其3个证型组的指标进行分析。结果:CHB虚证、实证及虚实夹杂3个组的CD4~+T细胞百分比均较对照组低;CD8~+T细胞百分比由高至低依次为实证组、虚实夹杂证组、对照组、虚证组,实证组CD4~+/CD8~+比值显著低于虚证组或对照组,3个组的B细胞百分比均高于对照组,NK细胞百分比低于对照组。结论:CHB存在着免疫调节紊乱,证候虚实分类与外周血淋巴细胞亚群之间存在一定的相关性,中医虚实证辨证结合免疫功能检测具有一定的临床意义。
[Abstract]:Objective: to understand the relationship between TCM syndrome deficiency and peripheral blood lymphocyte subsets in patients with chronic hepatitis B. methods: CHB patients were divided into syndromes deficiency syndrome, positive syndrome and deficiency and excess syndrome. The subsets of T B cells and NK cells in peripheral blood were detected, and the indexes of the three syndromes were analyzed. The percentages of CD4T cells in the three groups were lower than those in the control group. The percentage of CD8 ~ T cells was significantly lower in the group of deficiency syndrome than that in the group of deficiency syndrome or control group, and the ratio of CD4 ~ / CD8 ~ ~ in the group of deficiency syndrome and deficiency syndrome was significantly lower than that in the group of deficiency syndrome or control group in the order of CD8T cell percentage from high to low. The percentage of B cells in the three groups was higher than that in the control group, and the percentage of NK cells in the three groups was lower than that in the control group. There is a certain correlation between the classification of deficiency and deficiency of syndrome and lymphocyte subsets in peripheral blood. It is of certain clinical significance to detect the deficiency and deficiency of syndrome combined with immune function in TCM.
【作者单位】：桂林医学院附属医院;
【基金】：国家自然科学基金资助项目(81260602)-HBV感染不同免疫状态证候要素与外周血淋巴细胞亚群的关系
【分类号】：R259
【正文快照】： 我国一般人群乙型肝炎病毒(hepatitis B virus,HBV)流行率为7.18%,估计约9300万人为慢性HBV感染,其中慢性乙型肝炎(chronic hepatitis BCHB)患者约2000万例[1]。中西医结合防治CHB是我国独特的方法,中医药对人体免疫功能的影响是大多数中药抗病毒的主要机制之一,其治疗优势在

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