加减寿胎丸联合低分子肝素钠治疗肾虚血瘀型ACA阳性RSA的研究

发布时间：2018-01-03 09:20

本文关键词：加减寿胎丸联合低分子肝素钠治疗肾虚血瘀型ACA阳性RSA的研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察加减寿胎丸联合低分子肝素钠治疗肾虚血瘀型抗心磷脂抗体阳性复发性流产的临床疗效,从中医角度分析ACA阳性RSA的病机,从肾虚血瘀论治,为临床更好治疗免疫性复发性流产提供新方法。方法:选择ACA阳性、中医辨证为肾虚血瘀型的RSA患者73例,治疗组懫用加减寿胎丸联合低分子肝素钠的中西医结合方法,对照组单纯采用低分子肝素钠和地屈孕酮,比较两组患者妊娠5-8周内的β-HCG,E2,P水平;比较治疗后孕7、8、12周国际标准化比值(INR),D-二聚体测定;比较两组孕12周妊娠情况。结果:两组患者妊娠5-8周内β-HCG、E2有显著差异,(P0.05),比较两组P均无明显差异(P0.05)。治疗后测得孕7周时两组INR、D-二聚体无明显差别,(P0.05),孕8、12周两组患者INR、D-二聚体有明显差别(P0.05);两组孕12周者继续妊娠患者治疗前后中医症状积分有显著差异,(P0.05);两组孕12周妊娠情况比较有明显差异(P0.05)。结论:中药加减寿胎丸对提高孕早期β-HCG、E2有明显效果,对P影响不大,对妊娠早期胎儿生长发育有促进作用;对改善INR、D-二聚体有明显差异,加减寿胎丸联合低分子肝素钠改善凝血状态,可抑制血栓形成;妊娠12周时,对比治疗效果,治疗组妊娠成功者明显多于对照组;中药加减寿胎丸联合低分子肝素钠治疗ACA阳性RSA从妊娠进展、妊娠结局、凝血功能改善上明显优于低分子肝素钠和地屈孕酮。
[Abstract]:Objective: To observe the clinical effect of Shoutai Pill and anticardiolipin antibody combined with low molecular heparin in treating kidney deficiency and blood stasis type positive recurrent abortion, analyzing the pathogenesis of ACA positive RSA from the viewpoint of traditional Chinese medicine, treatment from kidney deficiency and blood stasis, provides a new method for better clinical treatment of immunological recurrent spontaneous abortion. Methods: ACA positive, TCM 73 cases of kidney deficiency and blood stasis in patients with RSA, combined with the method of treatment group Zhi modified Shoutai Pill Combined with low molecular weight heparin sodium by traditional Chinese medicine and Western medicine, the control group was treated with low molecular heparin and dydrogestrone, compared two groups of patients with pregnancy 5-8 weeks of beta -HCG, E2, P after treatment at 7,8,12 level; week international normalized ratio (INR), two D- dimer determination; comparison between the two groups at 12 weeks of pregnancy. Results: 5-8 weeks of pregnancy in beta -HCG patients in the two groups, E2 had significant difference (P0.05), there were no significant differences between the two groups (P P0.05). After treatment, measured at 7 weeks when Two INR, two D- dimer showed no significant difference (P0.05), 8,12 weeks of gestation in two groups of patients with INR, two D- dimer (P0.05); there are obvious differences between the two groups at 12 weeks of pregnancy to patients before and after treatment of TCM symptom score had significant difference (P0.05); the two group at 12 weeks of pregnancy there was significant difference between (P0.05). Conclusion: the traditional Chinese medicine decoction of Shoutai Pill on early pregnancy increased beta -HCG, E2 have obvious effect, little effect on the P of early pregnancy, fetal growth promoting effect; to improve the INR, D- two dimers have obvious difference between the modified Shoutai Pill Combined with low molecular weight heparin to improve the coagulation state, can inhibit thrombosis; at 12 weeks gestation, compared treatment, the treatment group pregnancy are significantly more than the control group; Chinese medicine modified Shoutai Pill Combined with low molecular weight heparin sodium in the treatment of ACA positive RSA in the progression of pregnancy, pregnancy outcome, coagulation function improved significantly better than low molecular weight heparin and dydrogestrone.

【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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