运用温阳化瘀法治疗心律失常（室性期前收缩）的临床研究

发布时间：2018-01-05 03:08

本文关键词：运用温阳化瘀法治疗心律失常（室性期前收缩）的临床研究　出处：《长春中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察温阳化瘀方剂“桂胶颗粒”在治疗心阳不振夹瘀型心律失常(室性期前收缩)方面的临床疗效及安全性,由此来证明温阳化瘀法的“桂胶颗粒”在临床上的安全性及有效性,进而为治疗心阳不振夹瘀型心律失常(室性期前收缩)从中医药角度来提供安全、有效的方案。方法:本次研究将72例患者随机分成每36例患者为1组的治疗组和对照组,应用平行对照的方法。治疗组应用的桂胶颗粒(由长春中医药大学附属医院免煎药房提供):桂枝1.5g,鹿角胶1.5g,紫石英1.5g,太子参0.5g,磁石1g,炙甘草1g,肉桂1g,巴戟天0.5g,川芎0.5g,石斛1g,砂仁1g,泽兰1g。(备注:以上生药1g相当于饮片10g),1天2次,取汁300ml,每次150ml,早晚温水冲服。对照组应用北京以岭药业有限公司生产的参松养心胶囊(批准文号:国药准字Z20030058):人参、麦冬、山茱萸、丹参、炒酸枣仁、桑寄生、赤芍、土鳖虫、甘松、黄连、南五味子、龙骨。服法:1天3次,每次4粒(1.6g)口服。通过上述72例病例(1个疗程28天)对两组药物的有效性及安全性的观察,进而做出客观的评价。结果:本研究实际入组病例72例,脱落及剔除病例各为0例。口服桂胶颗粒的治疗组在改善中医证候方面明显优于对照组,在中医症候改善的总有效率方面,治疗组为86.1%,对照组为66.7%,经统计数据分析(P=0.0250.05),差异明显。在治疗动态心电图室性期前收缩方面上,治疗组的总有效率为:86.1%,对照组为:66.7%,经统计数据分析(P=0.0380.05),差异明显。结论:温阳化瘀方剂桂胶颗粒与参松养心胶囊对比,能安全有效地治疗心心阳不振夹瘀型心律失常(室性期前收缩);治疗28天后,从动态心电图检查可见桂胶颗粒治疗心律失常(室性期前收缩)疗效确切,同时在中医症候的改善方面,明显优于对照组。因此,临床上运用桂胶颗粒对心阳不振夹瘀型心律失常(室性期前收缩)的治疗,疗效明显。
[Abstract]:Objective: to observe the clinical efficacy and safety of "Guijiao granule", a prescription for warming yang and removing blood stasis, in the treatment of cardiac arrhythmia (ventricular premature contraction). This proves the clinical safety and effectiveness of "Guijiao granule" of warming yang and removing blood stasis, and then provides safety from the perspective of traditional Chinese medicine for the treatment of cardiac arrhythmias (ventricular premature contraction). Methods: in this study, 72 patients were randomly divided into treatment group (group 1) and control group (n = 36). The treatment group was treated with Guijiao granules (provided by the decoction Room of Changchun University of traditional Chinese Medicine): Guizhi 1.5g, antler 1.5g, purple quartz 1.5g. Radix Pseudostellariae 0.5g, magnetite 1g, roasted liquorice 1g, cinnamon 1g, Morinda officinalis 0.5g, Chuanxiong 0.5g, Dendrobium 1g, Amomum villosum 1g. (note: above 1 g of raw medicine is equivalent to 10 g / d of drinking tablets twice, take the juice 300ml, 150ml each time. The control group was taken with warm water in the morning and evening. The control group was treated with Shensong Yangxin capsule produced by Beijing Yiling Pharmaceutical Co., Ltd. (approval number: Z20030058: ginseng, Ophiopogon, Cornus officinalis, Salvia miltiorrhiza, fried jujube kernel. Mulberry parasitism, Radix Paeoniae Alba, hillbilly, Gan Song, Coptis, Schisandra chinensis, keel. The efficacy and safety of the two groups were observed in 72 cases (a course of treatment for 28 days). Results: there were 72 cases in this study, 0 cases were dropped off and 0 cases were eliminated. The treatment group of oral Guijiao granule was superior to the control group in improving TCM syndrome. The total effective rate of TCM symptom improvement was 86.1 in the treatment group and 66.7 in the control group. The total effective rate of the treatment group was: 86.1% and that of the control group was 66.7%. Through statistical data analysis, the difference was obvious. Conclusion: the comparison between Guijiao granules and Shensong Yangxin capsule. It can safely and effectively treat cardiac arrhythmia (ventricular premature contraction). After 28 days of treatment, from the dynamic electrocardiogram examination, we can see that Guijiao granule is effective in the treatment of arrhythmia (ventricular premature contraction), at the same time, it is obviously superior to the control group in the improvement of TCM symptoms. Clinical application of Guijiao granule in the treatment of cardiac arrhythmia (ventricular premature contraction).
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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