丹红注射液对慢性稳定性心绞痛患者超敏C反应蛋白影响的研究

发布时间：2018-01-05 23:08

本文关键词：丹红注射液对慢性稳定性心绞痛患者超敏C反应蛋白影响的研究　出处：《黑龙江中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察丹红注射液对慢性稳定性心绞痛患者超敏C反应蛋白和血浆纤维蛋白原的影响,对其有效性与安全性做出初步评价。方法：选择2014年4月至2015年3月来自黑龙江中医药大学附属第一医院门诊及病房的36例慢性稳定性心绞痛患者,所有患者均符合纳入标准要求并自愿签署患者知情同意书,将入选的36例患者采用随机双盲安慰剂的方法分成治疗组和对照组,其中治疗组24例,对照组12例。治疗组采用氯化钠注射液250m1加丹红注射液40m1日一次静点；对照组患者予安慰剂氯化钠溶液290m1日一次静点,疗程14天,随访至第90天。记录试验前后患者心绞痛每周发作的次数,硝酸甘油停减率,西雅图心绞痛量表,心绞痛分级的变化,检测血脂,超敏C反应蛋白,血浆纤维蛋白原等数据或指标,对临床试验完成后所得的数据采用SPSS20.0软件进行分析,评估此次临床观察的疗效性与安全性,并随时记录试验中发生的不良事件。结果：与对照组相比,治疗组患者的超敏C反应蛋白与血浆纤维蛋白原水平降低差异有统计学意义(P0.05)；与对照组相比,治疗组患者血清Cr, BUN, ALT, AST水平无明显变化,差异无统计学意义(P0.05)。结论：1、丹红注射液可以降低超敏C反应蛋白和血浆纤维蛋白原水平。2、丹红注射液对血清BUN, Cr, ALT, AST水平无影响。
[Abstract]:Objective: To observe the effect of Danhong injection of C reactive protein and fibrinogen in patients with chronic stable angina hypersensitivity, to evaluate its effectiveness and safety. Methods: from April 2014 to March 2015 36 cases of patients with chronic stable angina from Heilongjiang University Of Chinese Medicine and outpatient ward of the First Affiliated Hospital, all patients met the inclusion criteria and signed informed consent voluntarily to patients, 36 patients will be selected by random double blind placebo were divided into treatment group and control group, 24 cases in treatment group, 12 cases in the control group. The treatment group used Sodium Chloride Injection 250m1 40m1 plus Danhong injection once a day; the control group were treated with placebo for Sodium Chloride Solution 290m1 once a day, a course of 14 days, up to ninetieth days. The number of records before and after the trial of weekly angina attack patients, nitroglycerin The rate, the Seattle angina questionnaire, angina grade changes, serum lipids, high sensitive C reactive protein, fibrinogen and so on clinical data or index, after completion of the test data is analyzed by SPSS20.0 software, to evaluate the efficacy of the clinical observation and safety, and to keep records of adverse events test in place. Results: compared with control group, group of high sensitive C reactive protein and fibrinogen levels of treatment to reduce the difference was statistically significant (P0.05); compared with the control group, treatment group, serum Cr, BUN, ALT, AST had no significant changes, the difference was not statistically significant (P0.05). Conclusion: 1, Danhong injection can reduce the high sensitive C reactive protein and fibrinogen level.2, Danhong Injection on serum BUN, Cr, ALT, AST had no effect on the level.

【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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