生物学指标NDKA、PARK7与中风病急性期气虚证及NIHSS评分的相关性

发布时间：2018-01-06 00:35

本文关键词：生物学指标NDKA、PARK7与中风病急性期气虚证及NIHSS评分的相关性　出处：《中华中医药杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:研究分析生物学指标NDKA、PARK7在缺血性中风病急性期的血清水平、气虚证评分及NIHSS评分的演变,进一步探究其与中风病急性期气虚证的相关性。方法:本研究纳入33例缺血性中风病急性期气虚证患者,检测其发病72h内、第7天、第14天PARK7、NDKA的血清水平,并采集3个时点的气虚证评分及NIHSS评分,同步纳入49名正常人作对照。结果:(1)研究发现中风病气虚证患者NDKA在3个时点与正常人比较差异有统计学意义(P0.01),PARK7在发病72h内、第7天差异有统计学意义(P0.05)。(2)NDKA在3个时点呈现逐渐上升趋势,NIHSS评分、气虚证评分呈逐渐下降趋势。(3)3个时点NDKA、PARK7与NIHSS均未发现相关性。NDKA在中风病第14天与气虚证具有高度负相关。结论:NDKA可能为中风病气虚证的一个保护性因素。
[Abstract]:Objective: to study and analyze the changes of serum level, qi deficiency syndrome score and NIHSS score of biological index NDKAA PARK7 in acute stage of ischemic apoplexy. Methods: 33 patients with acute deficiency of qi in ischemic stroke were included in this study, and their incidence was detected within 72 hours and 7 days after onset. On the 14th day, the serum levels of PARK7 and NDKA were collected, and the Qi deficiency and NIHSS scores were collected at three time points. Results the NDKA of patients with Qi deficiency syndrome of apoplexy was significantly different from that of normal subjects at three time points (P 0.01). Within 72 hours after the onset of PARK7, there was a statistically significant difference on the 7th day. Qi-deficiency syndrome score showed a gradual downward trend. (3) three time points of NDKA. There was no correlation between PARK7 and NIHSS. NDKA was negatively correlated with Qi deficiency syndrome on the 14th day of stroke. Conclusion: NDKA may be a protective factor of Qi deficiency syndrome of stroke.
【作者单位】：北京中医药大学东直门医院脑病科;
【基金】：国家自然科学基金项目(No.81173230) 重大新药创制科技重大专项课题“中药新药临床评价研究技术平台”(No.2011ZX09302-006-01)~~
【分类号】：R255.2
【正文快照】： 随着人口老龄化,中风已是目前发病率最高的疾病之一,严重影响人们的工作和生活。而中医药在中风病的预防、治疗、恢复方面发挥着重要作用,越来越引起人们重视。基于中医“辨证论治”的特色,临床在审视疾病的同时,需四诊合参以求证,以更好的审证求因、随证施法。因此临床上“病

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