原发性干燥综合征患者疲劳及相关因素的横断面调查

发布时间：2018-01-06 12:13

  本文关键词：原发性干燥综合征患者疲劳及相关因素的横断面调查　出处：《辽宁中医药大学》2016年硕士论文　论文类型：学位论文

  更多相关文章： 干燥综合征 疲劳 相关因素

【摘要】：目的:调查原发性干燥综合征患者疲劳概况,分析患者疲劳症状的相关因素,间接寻找疲劳的病因线索,为其防治提供临床依据。资料与方法:采用横断面调查方法,于2016年1月至2016年3月期间,在辽宁中医药大附属医院风湿科门诊通过随机抽样,对95名符合2002年干燥综合征国际分类(诊断)标准的原发性干燥综合征患者进行问卷调查。调查方式为面访及电话采访。内容包括:一般资料、临床特征及国内外公认量表评分(疲劳程度量表、视觉模拟量表、疲劳概况量表,流调用抑郁量表)。统计方法应用SPSS17.0建立数据库,采用t检验、卡方检验、Logistic回归分析、偏相关系数及多重线性回归分析等方法;P0.05为差异有统计学意义。结果:1.将FSS得分≥4定义为疲劳组,FSS得分4为非疲劳组。p SS相关性疲劳的发生率为44.2%。疲劳组患者CES-D评分、CRP、Ig G、C3均高于非疲劳组(P0.05)。2.单因素分析显示,性别、居住地、受教育程度等因素与p SS相关性疲劳的发生无关(P0.05);Logistic回归分析显示,p SS相关性疲劳与Ig G(OR 1.419[95%CI1.108-1.817])、抑郁情绪(OR 1.162[95%CI 1.047-1.290])、病程(OR 1.019[95%CI1.004-1.034])相关。3.95名p SS患者疲劳程度的偏相关分析显示,CES-D评分与各疲劳量表评分皆具有相关性。此外,Ig M、Ig A、Ig G等因素分别与FSS、VAS、Pro F、Pro F-S评分相关(P0.05)。多重线性回归分析显示,每组自变量对各疲劳量表评分变异的贡献分别为FSS(22.5%)、VAS(17.0%)、Pro F-S(48.7%)、Pro F-M(21.5%)。结论:Ig G水平增高、抑郁情绪加重、病程的延长均可使p SS相关性疲劳的发生风险增高;抑郁情绪可能为p SS患者疲劳程度的影响因素之一。因横断面调查有其局限性,故进一步寻找可能诱发疲劳的身心因素及病理机制,对临床有效缓解p SS患者疲劳症状有指导意义。
[Abstract]:Objective: To investigate patients with primary Sjogren syndrome fatigue related factors of fatigue symptoms, indirect search for clues to the etiology of fatigue, and provide clinical basis for its prevention and treatment. Materials and methods: a cross-sectional survey method, during the period from January 2016 to March 2016, in the Liaoning traditional Chinese medicine hospital outpatient department of rheumatism by random sampling, the 95 2002 with Sjogren syndrome (diagnosis) standard international classification of primary Sjogren syndrome patients were surveyed. The survey for the interview and telephone interview. The contents include: general data, clinical features and recognized at home and abroad scale (fatigue severity scale, visual analogue scale, general fatigue scale call flow, depression scale). The application of SPSS17.0 statistical methods to establish a database, using t test, chi square test, Logistic regression analysis, partial correlation coefficient and multiple linear regression analysis method; P0.05 the difference was statistically significant. Results: 1. the FSS score greater than 4 was defined as the fatigue group, FSS score of 4 for non fatigue group.P SS correlation between the incidence of fatigue for 44.2%. fatigue of patients with CES-D score, CRP, Ig, G, C3 were higher than those in non fatigue group (P0.05).2. univariate analysis showed that sex, residence, education and other factors and P SS correlation between the occurrence of fatigue independent (P0.05); Logistic regression analysis showed that P SS and Ig G related fatigue (OR 1.419[95%CI1.108-1.817]), depression (OR 1.162[95%CI 1.047-1.290]), duration (OR 1.019[95% CI1.004-1.034]).3.95 P partial correlation analysis showed the degree of fatigue in patients with SS the CES-D score, and the scores are associated with fatigue. In addition, Ig M, Ig A, Ig G and other factors respectively to FSS, VAS, Pro F, Pro F-S score (P0.05). Multiple linear regression analysis showed that each variable on the fatigue scale variation The contributions were FSS (22.5%), VAS (17%), Pro F-S (48.7%), Pro F-M (21.5%). Conclusion: Ig increased the level of G, increase the duration of depression, can make the P SS correlation between the occurrence of fatigue increased risk; depression may be one of the influencing factors of P SS patients with fatigue because the cross-sectional survey has its limitations, so further search for possible physical and mental factors induced fatigue and pathological mechanism, to effectively alleviate the clinical significance of P SS in patients with symptoms of fatigue.

【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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