补虚祛浊通络法对老年2型糖尿病轻度认知损害及相关因素的影响

发布时间：2018-01-07 12:27

本文关键词：补虚祛浊通络法对老年2型糖尿病轻度认知损害及相关因素的影响　出处：《长春中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本研究以“脏虚络痹”理论为指导,应用“补虚祛浊通络方”,对老年2型糖尿病轻度认知损害患者进行干预,验证其有效性及安全性,同时观察其对胰岛素抵抗相关指标的影响。方法:病例全部来自吉林省中医药科学院第一临床医院门诊患者72例,随机分为治疗组36例,对照组36例。两组均给予既往存在疾病药物治疗,治疗组给予口服补虚祛浊通络方,观察两组患者治疗前后中医证候疗效、简易精神状态量表(MMSE)、ADAS-Cog量表延迟词语回忆(ADAS-COG-DVR)、胰岛素敏感指数(ISI)=-In[空腹血糖(FPG)×空腹胰岛素(FINS)]、脂联素(APN)、瘦素(LPN)的变化。结果:两组临床总体疗效比较,治疗组总有效率52.8%,优于对照组的2.8%,差异有统计学意义(P0.05)。中医证候疗效比较,治疗组在改善遇事善忘、心悸、不寐、少气懒言、腰膝酸软、头晕耳鸣、夜尿频多、头重如裹、头痛如刺九个症状方面明显优于对照组,差异有统计学意义(P0.05)。两组认知量表(MMSE、ADAS-COG-DVR)积分治疗后比较,治疗组优于对照组,差异有统计学意义(P0.05)。观察患者血清APN、LPN、及ISI水平,治疗组治疗后血清APN水平升高,血清LPN水平降低,ISI水平提高,差异有统计学意义(P0.05)。结论:通过本研究证实,补虚祛浊通络法治疗老年2型糖尿病轻度认知损害方面疗效确切,安全性高,该方可能通过调节人体内分泌代谢,改善胰岛素抵抗,达到改善认知功能的作用。
[Abstract]:Objective: under the guidance of the theory of "zang-deficiency collateral-arthralgia" and "tonifying deficiency and turbid turbid Tongluo recipe", this study intervened the elderly patients with mild cognitive impairment of type 2 diabetes mellitus to verify its efficacy and safety. Methods: 72 outpatients from the first Clinical Hospital of Jilin Academy of traditional Chinese Medicine were randomly divided into treatment group (n = 36). The control group (36 cases) were treated with drugs for the past existing diseases, while the treatment group were given oral prescription of tonifying deficiency, removing turbid turbidity and dredging the collaterals. The curative effect of TCM syndrome and simple mental state scale (MMSE) were observed before and after treatment in the two groups. ADAS-COG-DVR, insulin sensitivity index (ISI) -In. [The changes of fasting blood glucose (FPG) 脳 fasting insulin (fins), adiponectin (APN), leptin (LPN). Results: compared with the two groups, the total effective rate of the treatment group was 52.8%. Better than the control group of 2.8, the difference is statistically significant P0.05.Compared with the curative effect of TCM syndromes, the treatment group in improving good memory, palpitations, sleepless, less Qi lazy speech, weak waist and knee, dizziness tinnitus. The nocturnal urination frequency, head weight as wrapped, headache such as prick nine symptoms were significantly better than the control group, the difference was statistically significant (P 0.05). The two groups of cognitive scale MMSE. After ADAS-COG-DVR) treatment, the treatment group was better than the control group, the difference was statistically significant (P 0.05). In the treatment group, the level of serum APN increased and the level of serum LPN decreased. The difference was statistically significant (P 0.05). The method of tonifying deficiency and removing turbidity and dredging collaterals is effective and safe in treating mild cognitive impairment of senile type 2 diabetes mellitus. The prescription may improve the cognitive function by regulating endocrine metabolism and improving insulin resistance.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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