代谢综合征女性人群体质类型及相关因素分析

发布时间：2018-01-07 17:09

本文关键词：代谢综合征女性人群体质类型及相关因素分析　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:代谢综合征(Metabolic Syndrome,MS)是一种复杂的代谢紊乱综合征,是心血管疾病和糖尿病的重要危险因素,和女性代谢性疾病如多囊卵巢综合征(PCOS)、子宫内膜癌、乳腺癌等的发生有密切相关性。本次研究选择代谢综合征女性患者人群,采用《中医体质分类与判定表》判定体质类型和生化指标检测,观察女性MS的主要体质分布特点,分析MS与年龄的相关性,血压与体重指数(body mass index,BMI)、空腹血糖(fasting blood-glucose,FPG)、甘油三酯(triglyceride,TG)、高密度脂蛋白-胆固醇(highdensity lipoprotein-cholesterol,HDL-C)的关系,总结中医体质和MS的相关性,以期通过调理体质来改善MS的临床症状,延缓疾病的发展进程,并进一步为防止相关妇科疾病的发生提供新的思路和方法。方法:选择2015年06月-2016年12月就诊于黑龙江中医药大学附属第一医院治未病中心科室的女性患者1000例,按照国际糖尿病联盟2005年发布的MS全球共识纳入筛选,对患者进行血脂、空腹血糖、血压、BMI、腹围等相关指标的测量,符合纳入标准的为观察组共297例,不符合的健康人群为对照组共248例。体质量调查由专业人员指导患者填写《中医体质辨识量表》,之后数据录入数据库,用SPSS22.0系统对数据进行统计分析,得出结论。结果:1、观察组中医体质分布比例:痰湿质72例(24.24%)气虚质48例(16.16%)阳虚质45例(15.15%)气郁质42例(14.14%)阴虚质24例(8.08%)=血瘀质 24 例(8.08%)湿热质 21 例(7.0 07%)特禀质 12 例(4.04%)平和质9例(3.03%);对照组中医体质分布比例:阳虚质45例(18.15%)气郁质33例(13.31%)阴虚质30例(12.10%)痰湿质28例(11.29%)平和质27例(10.89%)血瘀质25例(10.08%)湿热质24例(9.68%)气虚质22例(8.87%)特禀质14例(5.65%)。观察组与对照组体质类型分布上具有显著性差异(P0.05)。2、MS女性患者年龄和体质分布上无明显统计学差异(P0.05)。3、以血压分层研究,与正常组比较,高血压组BMI、FPG和TG水平均偏高,HDL-C水平偏低,差异具有统计学意义(P0.05)。4、痰湿质和气虚质最终进入回归方程中,相对危险度分别为EXP=3.000,EXP=2.545(P0.05)。结论:1、MS女性人群以痰湿质为主,其次为气虚质、阳虚质、气郁质、阴虚质和血瘀质、湿热质、特禀质、平和质;MS与非MS女性人群在体质分布上有显著差异。2、MS女性人群年龄和9种体质类型分布无明显关系。3、MS女性人群中高血压患者与血压正常人群相比,肥胖和糖脂代谢紊乱更加严重,高血压患者患MS的风险较大。4、痰湿质和气虚质对MS的发病有影响,可能是MS的危险体质。
[Abstract]:Objective: metabolic syndromes (MS) is a complex metabolic disorder syndrome and an important risk factor for cardiovascular disease and diabetes mellitus. And female metabolic diseases such as polycystic ovary syndrome (PCOS), endometrial carcinoma, breast cancer and so on are closely related. This study selected female patients with metabolic syndrome. The classification and judgement table of TCM constitution was used to determine the physique type and biochemical index, to observe the main physique distribution characteristics of female MS, and to analyze the correlation between MS and age. Blood pressure and body mass index (BMIG), fasting blood glucose and glucose (FPG). Triglyceride triglyceride (TGN), high density lipoprotein cholesterol (HDL-C) lipoprotein-cholesterol. The correlation between TCM constitution and MS is summarized in order to improve the clinical symptoms of MS and delay the development of the disease by regulating the physique. It also provides new ideas and methods for preventing the occurrence of gynecological diseases. From June 2015 to December 2016, 1 000 female patients were selected from the department of the Center for treatment and Prevention in the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. According to the MS global consensus released by the International Diabetes Federation in 2005, the patients were selected to measure blood lipids, fasting blood glucose, blood pressure BMIs, abdominal circumference and so on. 297 cases in the observation group and 248 cases in the control group were in accordance with the inclusion criteria. The investigation of body mass was conducted by the professionals to complete the TCM physique Identification scale. After that, the data is entered into the database, and the data is statistically analyzed with SPSS22.0 system, and the conclusion is drawn. The result is: 1. The distribution ratio of TCM constitution in observation group was: phlegm dampness in 72 cases, Qi deficiency in 48 cases, Yang deficiency in 45 cases, Qi stagnation in 42 cases, and Qi stagnation in 42 cases, respectively. There were 24 cases of yin deficiency and 24 cases of blood stasis, 24 cases of blood stasis, 21 cases of dampness and heat, 21 cases of dampness and heat, 7.07% of nature, 12 cases of nature, 4.04%) and 9 cases of mild quality (. 3.03; In the control group, the distribution ratio of TCM constitution was: Yang deficiency in 45 cases, Yang deficiency in 45 cases, Qi stagnation in 33 cases, Yin deficiency in 30 cases, phlegm dampness in 28 cases, and phlegm dampness in 28 cases. Calming 27 cases (10.89) blood stasis 25 cases (10.08) dampness and heat in 24 cases (9.68) Qi deficiency 22 cases (8.87)) the intrinsic quality is 14 cases (5.65%). There was significant difference in the distribution of physique type between the observation group and the control group (P 0.05). There was no significant difference in age and physique distribution in female patients with MS (P0.05. 3). Compared with normal group, BMIFPG and TG levels in hypertension group were higher than those in normal group. The level of HDL-C was low, the difference was statistically significant (P0.05. 4). Phlegm and dampness and deficiency of qi eventually entered the regression equation, and the relative risk was EXP=3.000. Conclusion the female population of MS was composed of phlegm and dampness, followed by qi deficiency, yang deficiency, qi stagnation, yin deficiency and blood stasis, dampness and heat, special nature and calmness. There was significant difference in physical distribution between MS and non-MS female population. 2. There was no significant relationship between age and distribution of 9 physique types in MS female population. Compared with normal blood pressure, obesity and disorder of glucose and lipid metabolism were more serious in female patients with MS. The risk of MS was higher in hypertensive patients. Phlegm dampness and deficiency of qi had influence on the incidence of MS. May be the dangerous constitution of MS.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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