基于Meta分析的注射用丹参多酚酸盐治疗急性脑梗死临床评价研究

发布时间：2018-01-07 17:19

本文关键词：基于Meta分析的注射用丹参多酚酸盐治疗急性脑梗死临床评价研究　出处：《药物流行病学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:运用Meta分析方法评价注射用丹参多酚酸盐辅助西医常规治疗急性脑梗死的有效性、安全性。方法:计算机检索the Cochrane Library,Pub Med、Sino Med、中国知网、维普期刊数据库和万方数据库有关注射用丹参多酚酸盐治疗急性脑梗死的随机对照试验文献,检索时限为各数据库建库至2016年8月。采用Cochrane风险评价表评价其研究质量,提取资料通过Rev Man 5.3进行Meta分析。结果:共纳入22个随机对照试验,累计2 762名患者。Meta分析结果显示,注射用丹参多酚酸盐辅助西医常规可提高临床疗效总有效率(RR=1.29,95%CI:1.21~1.37,P0.000 01)和患者日常生活活动能力(MD=8.90,95%CI:7.03~10.77,P0.000 01),改善神经功能缺损(MD=-3.59,95%CI:-4.31~-2.87,P0.000 01),改善血液流变学指标,降低患者血清C反应蛋白浓度。有4篇文献明确无不良反应,2篇研究报道了共12例不良反应,其他文献均未对安全性做出说明。结论:注射用丹参多酚酸盐辅助西医常规治疗急性脑梗死具有较好的疗效,值得临床推广,对其安全性尚需进一步探讨。
[Abstract]:Objective: To study the evaluation method for injection is effective, salvianolate auxiliary routine western medicine in the treatment of acute cerebral infarction. Methods: the safety of Meta Cochrane Library Pub searched the, Med, Sino, Med, China CNKI, VIP database and Wanfang database about shot randomized controlled trials on treatment of acute cerebral infarction with salvianolic acid salt, the retrieval time for each database to August 2016. The Cochrane risk assessment table to evaluate the quality of research, the data extracted from the Meta analysis by Rev Man 5.3. Results: a total of 22 randomized controlled trial, a total of 2762 patients with the results of.Meta analysis showed that salvianolate injection can improve the clinical auxiliary routine the total effective rate (RR=1.29,95%CI:1.21~1.37, P0.000 01) and activities of daily living in patients (MD=8.90,95%CI:7.03~10.77, P0.000 01), and improve neurological function Defect (MD=-3.59,95%CI:-4.31~-2.87, P0.000 01), improving blood rheology, lower serum C-reactive protein concentrations in patients with C. There are 4 articles clearly without adverse reaction, 2 studies reported adverse reactions in 12 cases, other documents were not made for safety. Conclusion: injection of salvianolate auxiliary routine the treatment of acute cerebral infarction has good curative effect, worthy of promotion, to further explore the security needs.

【作者单位】：北京中医药大学中药学院;
【基金】：国家自然科学基金课题(编号:81473547、81673829)
【分类号】：R277.7
【正文快照】： 急性脑梗死又称为急性缺血性脑卒中,是最常见起脑部供血障碍,导致脑组织缺氧、缺血性坏死或软的卒中类型,约占全部脑卒中的60%~80%[1]。急化,微循环障碍及继发的缺血再灌注损伤,而出现相性脑梗死的形成是因为脑内血栓形成或动脉硬化,引应区域脑神经功能缺损[2],具有较高的发病

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