宣白承气汤对急性呼吸窘迫综合征患者炎性因子TNF-α、IL-1β调控及力学指标研究

发布时间：2018-01-07 22:16

本文关键词：宣白承气汤对急性呼吸窘迫综合征患者炎性因子TNF-α、IL-1β调控及力学指标研究　出处：《实用医学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:研究宣白承气汤对急性呼吸窘迫综合征患者炎性因子肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)的调控及力学指标的影响及其作用机制。方法:随机选取2016年1-8月入住重症医学科急性呼吸窘迫综合征机械通气患者60例,依随机表对照法随机分为对照组30例和治疗组30例,均给予常规治疗并辅以机械通气,治疗组加用宣白承气汤。均持续治疗1周后比较治疗前后两组TNF-α、IL-1β和白介素-10(IL-10)等炎性因子,气道峰压(PIP)、平台压(Pplat)、用力肺活量(FVC)、1秒用力呼气量(FEV1)、氧合指数(Pa O2/Fi O2)等呼吸力学指标的变化差异。结果:治疗组治疗后的TNF-α、IL-1β水平明显下降,IL-10水平上升,且不良反应较少,患者改善情况明显优于对照组,差异具有统计学意义(P0.05)。且治疗组PIP、Pplat等改善也很显著,差异有统计学意义(P0.05)。治疗组产生的不良反应较少。结论:宣白承气汤能改善机械通气患者呼吸力学指标及肺功能,减轻炎症的反应,效果显著。
[Abstract]:Objective: to study the effect of Xuanbai Chengqi decoction on inflammatory factor tumor necrosis factor- 伪 (TNF- 伪) in patients with acute respiratory distress syndrome (ARDS). Interleukin-1 尾 (IL-1 尾). Methods: 60 patients with acute respiratory distress syndrome (ARDS) admitted from 2016 to August were randomly selected. According to the random table control method, 30 cases in the control group and 30 cases in the treatment group were randomly divided into control group and treatment group. All of them were given routine treatment with mechanical ventilation. The treatment group was treated with Xuanbai Chengqi decoction. After 1 week of continuous treatment, the inflammatory factors such as TNF- 伪, IL-1 尾 and IL-10 were compared before and after treatment. Platform pressure, forced vital capacity (FV), 1 seconds forced expiratory volume (FEV1). Results: after treatment, the level of TNF- 伪 and IL-1 尾 in the treatment group decreased significantly and the level of IL-10 increased. And the adverse reactions were less, the improvement of patients was significantly better than that of the control group, the difference was statistically significant (P 0.05). And the treatment group PIP Pplat was also significantly improved. Conclusion: Xuanbai Chengqi decoction can improve respiratory mechanics index and lung function of patients with mechanical ventilation and alleviate inflammatory reaction.
【作者单位】：河南中医药大学第一附属医院重症医学科;郑州大学第三附属医院产后康复科;
【基金】：河南省中医药科学研究专项课题(编号:2014ZY02029)
【分类号】：R259
【正文快照】： 急性呼吸窘迫综合征是一种急性低氧性呼吸功能不全的危重症,病因复杂,病情恶劣且病死率较高[1]。目前认为其是全身性炎性反应综合征(SIRS)在肺部的表现。因内源性或外源性的因素引发体内炎性细胞失控,释放大量的炎性介质,两者共同损伤机体,且炎性介质又攻击炎性细胞,周而复始,

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