虚寒呕吐模型的复制和吴茱萸汤的止呕作用研究

发布时间：2018-01-08 02:05

本文关键词：虚寒呕吐模型的复制和吴茱萸汤的止呕作用研究　出处：《中华中医药学刊》2017年05期 　论文类型：期刊论文

【摘要】：目的:为客观准确评价吴茱萸汤的止呕作用,本研究首次尝试顺铂致呕模型的基础上。方法:采用给予苦寒中药大黄的方式制备了病症结合的虚寒呕吐模型,并基于两种呕吐模型,分别从体质量、生化指标和脏器指数等机体生理生理病理状态,以及异食癖等行为学多个方面对吴茱萸汤的止呕作用进行了评价。结果:大鼠口饲大黄一段时间后表现出了明显的虚寒状态和一定程度的病理指标的变化,而对证给予吴茱萸汤后这种病理状态和病理指标均有较为明显的改善,而不具有虚寒状态的顺铂对照组大鼠给予吴茱萸汤治疗后反而加重了病理指标的变化;吴茱萸汤对两种呕吐模型均有显著的止呕作用(P0.01),但对大黄加顺铂制备的虚寒呕吐动物模型的作用优于单纯顺铂制备的呕吐模型(P0.01)。结论:该方法制备的病症结合模型比顺铂致呕模型更适于吴茱萸汤等中医复方治疗虚寒呕吐药效学的评价研究,本研究结果也从以方测证和方证相应的角度反映了该方法复制虚寒呕吐模型的可行性和合理性。
[Abstract]:Objective: in order to evaluate the antiemetic effect of Evodia rutaecarpa decoction, the model of emesis induced by cisplatin was first tried in this study. Methods: the model of asthenia and vomiting was established by using rhubarb, a Chinese medicine for bitter cold. Based on the two models of vomiting, physiological physiological and pathological status of body mass, biochemical index and visceral index were analyzed respectively. The antiemetic effect of Evodia rutaecarpa was evaluated from many aspects of behavioral science. Results: after feeding rhubarb orally for a period of time, rats showed obvious deficiency and cold state and the change of pathological index to a certain extent. However, the pathological state and pathological indexes were improved obviously after the treatment of Evodia rutaecarpa decoction, but the changes of pathological indexes were aggravated in the cisplatin control group which did not have deficiency and cold state after the treatment of Evodia rutaecarpa decoction. Evodia rutaecarpa decoction had a significant antiemetic effect on both models of vomiting (P0.01). But the effect of rhubarb plus cisplatin on asthenia and vomiting animal model was better than that of cisplatin alone (P0.01). Conclusion: compared with cisplatin induced nausea model, the combined model is more suitable for the evaluation of pharmacodynamics of traditional Chinese medicine compound such as Wuzhuyu decoction in the treatment of asthenia and vomiting. The results also reflect the feasibility and rationality of this method in replicating the model of asthenia and vomiting.
【作者单位】：哈尔滨商业大学生命科学与环境科学研究中心;中国中医科学院中药研究所;中国中医科学院研究生院;
【基金】：国家自然科学基金面上项目(81373986,81473372,81274112);国家自然科学基金青年项目(81403125,81403322) 北京市自然科学基金项目(7152106)
【分类号】：R256.31
【正文快照】： 吴茱萸汤是出自张仲景《伤寒论》的经典名方,仅由吴茱萸、党参、生姜、大枣四味药组成,具有温胃补虚之效,用治胃气虚寒所致阳明寒呕、少阴吐利、厥阴头痛[1-2]。该方药味虽少,却配伍精妙,方中吴茱萸既可祛寒降逆又能舒肝温胃,党参益气健脾,温中补虚,生姜温胃降逆,与吴茱萸相得

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