通阳益气化痰逐瘀法联合吴茱萸贴敷治疗早期糖尿病下肢血管病变的临床研究

发布时间：2018-01-08 22:17

本文关键词：通阳益气化痰逐瘀法联合吴茱萸贴敷治疗早期糖尿病下肢血管病变的临床研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:探讨通阳益气化痰逐瘀法联合吴茱萸穴位贴敷治疗早期2型糖尿病下肢血管病变(diabetic lower extremity vascular disease,DLEVD)的有效性及安全性,为中医药在2型糖尿病下肢血管病变早期防治领域提供新的思路。方法:将60例早期LDEVD患者随机分为治疗组和对照组。治疗组给予导师依据通阳益气、化痰逐瘀法自拟的中药汤剂“通脉化痰汤”联合吴茱萸粉穴位贴敷(涌泉穴);对照组予常规西药治疗。3个月为1个疗程,采集患者治疗前后症状积分、间歇性跛行的距离积分、空腹及餐后2h血糖水平、糖化血红蛋白、下肢动脉血管彩超、ABI、血脂情况,并采用SPSS17.0进行统计学分析。结果:两组治疗后中医症候积分、跛行距离积分、血浆纤维蛋白原、血脂、下肢动脉彩色多普勒超声积分较治疗前均明显改善(P0.05),除血脂两组比较无统计学差异外(P0.05),其他观察指标比较治疗组均优于对照组(P0.05),观察过程中未见明显不良反应。结论:通阳益气化痰逐瘀法联合吴茱萸穴位贴敷可显著改善DLEVD早期临床症状体征及血脂水平、下肢动脉硬化及血流情况,减低血液粘稠度,缩小下肢动脉斑块,安全性较高,值得进一步研究推广。
[Abstract]:Objective: to explore the treatment of early type 2 diabetes mellitus (T2DM) with Tongyang Yiqi Huatan Zhuayu method combined with Evodia rutaecarpa acupoint application in the treatment of lower extremity vascular disease. Diabetic lower extremity vascular disease. The effectiveness and security of DLEVD. To provide a new idea for the early prevention and treatment of lower extremity vascular diseases in type 2 diabetes mellitus. Methods:. 60 cases of early LDEVD patients were randomly divided into treatment group and control group. The traditional Chinese medicine decoction "Tongmai Huatan decoction" combined with Evodia rutaecarpa powder acupoint application (Yongquan acupoint) was prepared by removing phlegm and removing blood stasis. The control group was treated with routine western medicine. Three months was a course of treatment. The symptom score, distance score of intermittent claudication, fasting and 2 h postprandial blood glucose level and glycosylated hemoglobin were collected before and after treatment. Results: the TCM symptom score, claudication distance integral, plasma fibrinogen, blood lipids were analyzed by SPSS17.0. Lower extremity artery color Doppler ultrasound scores were significantly improved than before treatment P0.05, except the two groups there was no significant difference in blood lipid (P0.05). The other observation indexes were better in the treatment group than in the control group (P0.05). Conclusion: the combination of Tongyang Yiqi and phlegm removing blood stasis method combined with Evodia rutaecarpa acupoint application can significantly improve the early clinical symptoms and signs of DLEVD and the level of blood lipids. The lower extremity arteriosclerosis and blood flow can reduce the blood viscosity and reduce the arterial plaque of lower extremity, which is worthy of further study and popularization.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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