防风通圣丸治疗单纯性肥胖的临床疗效观察及对LP、APN的影响

发布时间：2018-01-09 15:08

本文关键词：防风通圣丸治疗单纯性肥胖的临床疗效观察及对LP、APN的影响　出处：《黑龙江中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察防风通圣丸治疗脾胃湿热型单纯性肥胖病的临床疗效及对瘦素(leptin, LP)、脂联素(adiponectin, APN)的影响。方法：将符合纳入标准的72例单纯性肥胖患者随机分为治疗组和对照组,每组各36例。治疗组采用基础治疗联合防风通圣丸,对照组采用基础治疗。各组疗程均为3个月。观察两组患者治疗前后体重、BMI、腰臀比(WHR)、中医症状积分、血脂(包括TG、TC、LDL-C)及LP、APN水平的变化。结果：1.在体重、BMI及WHR方面,治疗组治疗前后比较,有显著差异(P0.01),疗效优于对照组,差异具有统计学意义(P0.05)。2.在中医症状方面,治疗组与对照组进行有效率比较,差异有统计学意义(P0.05)；治疗组各项症状积分治疗前后比较,均有显著差异(P0.01),而对照组治疗前后比较,在口渴喜饮、口苦口臭、脘腹胀满、大便秘结以及消谷善饥症状方面,差异显著(P0.01)；治疗组治疗后与对照组相比,差异具有统计学意义(P0.05),疗效优于对照组。3.两组患者组内治疗前后的比较,血清LDL-C,两组P值均0.05,差异无统计学意义。血清TC和血清TG,治疗组治疗前后相比,具有显著差异(P0.01),对照组治疗前后相比,差异具有统计学意义(P0.05)；两组治疗后比较,差异有统计学意义(P0.05),治疗组优于对照组。4.LP、APN水平,治疗组治疗前后比较,具有显著差异(P0.01),而对照组治疗前后比较,差异具有统计学意义(P0.05)；两组治疗后比较,差异具有统计学意义(P0.05),治疗组优于对照组。5.两组患者治疗前后血常规、尿常规、肝功、肾功均未见异常。结论：1.防风通圣丸治疗脾胃湿热型单纯性肥胖病,可显著减轻患者体重,明显减小BMI和WHR。2.防风通圣丸能够显著改善脾胃湿热型单纯性肥胖病患者的中医症状。3.防风通圣丸治疗脾胃湿热型单纯性肥胖病,可明显降低血清TG和TC水平。4.防风通圣丸可明显降低脾胃湿热型单纯性肥胖患者的LP水平,明显升高APN水平。
[Abstract]:Objective: to observe the clinical effect of Fangfeng Tongsheng pills on simple obesity of damp-heat type of spleen and stomach and to observe the effect of leptin leptin, LPU and adiponectin on spleen and stomach damp-heat type. Methods: 72 patients with simple obesity were randomly divided into treatment group and control group with 36 cases in each group. The treatment group was treated with basic treatment combined with Fangfeng Tongsheng pills. The patients in the control group were treated with basic therapy for 3 months. BMIs, WHR, TCM symptom scores and blood lipids (including TGG TC) were observed before and after treatment. Results: 1. In terms of body weight and WHR, there were significant differences before and after treatment in the treatment group (P 0.01), and the curative effect was better than that in the control group. In terms of TCM symptoms, the effective rate of the treatment group was compared with that of the control group, and the difference was statistically significant (P 0.05). Before and after treatment, there were significant differences in the scores of symptoms in the treatment group, while in the control group, there was a significant difference before and after treatment, in thirst, bitter halitosis and abdominal distension. There were significant differences in the symptoms of great constipation and good hunger (P 0.01). Compared with the control group, the treatment group after treatment, the difference was statistically significant (P 0.05), the curative effect was better than the control group. 3. The comparison between the two groups before and after treatment, serum LDL-C. Serum TC and TGwere significantly different before and after treatment in the treatment group and the control group before and after treatment. The difference was statistically significant (P 0.05). After treatment, the difference between the two groups was statistically significant, the treatment group was better than the control group. 4. The level of APN in the treatment group was significantly different before and after treatment (P 0.01). In the control group, the difference was statistically significant before and after treatment (P 0.05). Two groups after treatment, the difference was statistically significant, the treatment group is better than the control group. 5. before and after treatment of the two groups of patients blood routine, urine routine, liver function. Conclusion 1. Fangfeng Tongsheng pills can significantly reduce the weight of patients with simple obesity of damp-heat type of spleen and stomach. Significantly reduce BMI and WHR.2.Fangfeng Tongsheng pills can significantly improve the spleen and stomach damp-heat type of simple obesity symptoms .3.Fangfengtongsheng pills in the treatment of spleen and stomach damp-heat simple obesity. Fangfeng Tongsheng pills could significantly reduce LP level and increase APN level in simple obesity patients with damp-heat type of spleen and stomach.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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