中药内服治疗原发性骨质疏松症的系统评价

发布时间：2018-01-09 15:18

本文关键词：中药内服治疗原发性骨质疏松症的系统评价　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：以已发表的内服中药治疗原发性骨质疏松症的相关临床随机对照研究文献为研究对象,运用系统评价的方法评估内服中药治疗原发性骨质疏松症的疗效及文献质量,为中医药在治疗原发性骨质疏松症方面提供理论依据和参考。方法：参照Cochrane协作网的检索策略,通过计算机检索Cochrane Library(2016年第4期)、MEDLINE(1979～2016年02月)、EMbase(1979～2016年02月)、中国生物医学文献数据库(CBM,1980～2016年02月)、中国知网(CNKI,1984-2016年02月)、维普中文科技期刊数据库(VIP,1994～2016年02月)。人工检索与内服中药治疗原发性骨质疏松症相关的临床随机对照研究文献,依据统一的纳入排除标准,对纳入研究的文献质量进行评估。采用Meta分析方法对患者用药后总体疗效、腰椎、股骨颈、股骨大粗隆、ward三角、跟骨骨密度以及肝肾功能、血液流变学指标进行分析。统计软件采用Cochrane协作网提供的RevMan5.3。结果：纳入9篇文献,共计1372例原发性骨质疏松症患者。分析结果表明：内服中药治疗组较对照组总体有效率高,相比有统计学差异(P0.01)；内服中药能够显著提高患者腰椎[RR=1.30,95%CI(1.11,1.51),P0.00001]和股骨颈[MD=0.03,95%CI(0.01,0.05),P=0.007]骨密度,股骨粗隆、ward三角以及跟骨方面差异无统计学意义(P0.05)。此外,中药能够增加患者血清中骨钙素、1,25(OH2)D3含量,同时改善血液流变学相关指标。结论：依据本次研究的结果可知,内服中药对原发性骨质疏松症具有一定疗效。但由于本次调查研究存在方法学和样本上的局限,上述结论有待选择更大样本的临床随机对照试验加以验证,本文的结论仅拥有一定的参考价值。
[Abstract]:Objective: to study the published literature of randomized controlled clinical study on the treatment of primary osteoporosis with traditional Chinese medicine. To evaluate the efficacy and literature quality of traditional Chinese medicine in the treatment of primary osteoporosis by means of systematic evaluation. To provide theoretical basis and reference for TCM in the treatment of primary osteoporosis. Methods: referring to the search strategy of Cochrane cooperation network. Cochrane Library (issue 4 of 2016) was searched by computer. EMbase from 1979 to February 2016, China Biomedical Literature Database (CBM) from 1980 to February 2016, CNKI from China. February, 1984-2016, VIP, Weipu Chinese Science and Technology Journal Database. From 1994 to February 2016. To search the literature of randomized controlled clinical study related to the treatment of primary osteoporosis with traditional Chinese medicine, according to the unified inclusion and exclusion criteria. The quality of literature included in the study was evaluated. Meta analysis was used to evaluate the overall efficacy of the treatment, lumbar spine, femoral neck, femoral trochanter triangle, calcaneal bone mineral density and liver and kidney function. The hemorheology index was analyzed. The statistical software was provided by Cochrane collaboration Network, Revman 5.3. Results: 9 articles were included. There were 1372 patients with primary osteoporosis. The results showed that the total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P 0.01). Chinese herbal medicine can significantly improve the lumbar vertebrae of patients. [RRN 1.30 ~ 95CIQ 1.111.51 P0.00001] and neck of femur. [The bone mineral density (BMD) and trochanter of femur were 0.03 ~ 95%. There was no significant difference in ward triangle and calcaneal bone (P 0.05). In addition, Chinese medicine could increase the serum osteocalcin (OH2D3) content in patients. At the same time improve the hemorheology related indicators. Conclusion: according to the results of this study. Oral Chinese medicine has a certain curative effect on primary osteoporosis. However, due to the limitations of methodology and samples in this investigation, the above conclusions need to be verified by a larger sample of clinical randomized controlled trials. The conclusion of this paper only has certain reference value.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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