仙车饮治疗卵巢癌术后绝经综合征的临床观察

发布时间：2018-01-10 20:03

本文关键词：仙车饮治疗卵巢癌术后绝经综合征的临床观察　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察仙车饮治疗卵巢癌术后绝经综合征的临床疗效与安全性,为妇科恶性肿瘤术后绝经综合征患者提供一种安全有效的中医药治疗方法,提高患者的生存质量。方法:收集2015年05月～2016年12月期间就诊于黑龙江中医药大学附属第一医院妇科门诊,符合纳入标准的卵巢癌术后绝经综合征患者30例。通过自身前后对照的研究方法,给予仙车饮治疗患者3个月。观察患者治疗后临床总疗效,治疗后中医证候疗效,治疗前后改良Kupperman症状积分、中医症状评分、中医单项症状评分、肿瘤病人生命质量量表评分、包括血清CA125水平在内的安全性指标的变化。结果:1、临床总疗效判定:治疗后患者临床总有效率为76.67%,其中0例痊愈,4例显效,19例有效,7例无效。2、中医证候疗效判定:治疗后患者中医证候疗效的总有效率为93.33%,其中5例痊愈,15例显效,8例有效,2例无效。3、改良Kupperman症状积分比较:治疗后患者改良Kupperman症状积分较治疗前下降,治疗前后差异有统计学意义(P0.01)。说明仙车饮能降低改良Kupperman症状积分,可有效缓解患者绝经综合征症状。4、中医症状评分比较:治疗后患者中医症状评分较治疗前下降,治疗前后差异有统计学意义(P0.01)。说明仙车饮能降低中医症状评分,可有效缓解患者肾阴阳两虚症状。5、中医单项症状评分比较:治疗后患者中医单项症状评分较治疗前下降,治疗前后差异有统计学意义(P0.01)。说明仙车饮能降低中医单项症状评分,可有效缓解各项中医症状。6、肿瘤病人生命质量量表评分比较:治疗后患者肿瘤病人生命质量量表评分较治疗前下降,治疗前后差异有统计学意义(P0.01)。说明仙车饮能够降低肿瘤病人生命质量量表评分,有效缓解肿瘤病人临床相关症状,提高患者的生存质量。7、安全性判定:患者服药治疗后未产生明显不良反应,无临床不良事件发生。血清CA125治疗前后无异常,治疗前后比较差异无统计学意义(P0.05)。复查肝功能,肾功能无异常。表明仙车饮治疗卵巢癌术后绝经综合征安全性良好。结论:仙车饮能够有效的缓解卵巢癌术后绝经综合征患者的临床症状,改善患者肾阴阳两虚的中医证候,提高患者的生存质量,并且安全性良好。
[Abstract]:Objective: To observe the XCD clinical efficacy and safety of treatment of ovarian cancer after menopause syndrome, provide a safe and effective Chinese medicine treatment for postoperative gynecological malignant tumor patients with menopausal syndrome, improve the quality of life of patients. Methods: from 2015 05 to December 2016 during the treatment in the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine Department of gynaecology outpatient service, in accordance with the inclusion criteria of ovarian cancer after menopause syndrome in 30 patients. Through the study of the method of self-control, given XCD treatment in 3 months. Patients were observed after treatment clinical curative effect after treatment of TCM syndrome curative effect before and after treatment, improved Kupperman symptom score, TCM symptom score, TCM symptom score, scores of quality of life of cancer patients, safety index changes, including the level of serum CA125. Results: 1, to determine the total clinical efficacy: after treatment of patients The total clinical effective rate was 76.67%, of which 0 cases were cured, 4 cases were cured, 19 cases effective, 7 cases invalid.2, determine the TCM syndrome curative effect: the curative effect of TCM syndrome in patients after treatment the total effective rate was 93.33%, of which 5 cases were cured, 15 cases were cured, 8 cases effective, 2 cases invalid.3, comparison the modified Kupperman symptom score: after treatment of patients with modified Kupperman symptom score decreased than that before treatment, there were significant differences before and after the treatment (P0.01). It can reduce the XCD modified Kupperman symptom score, can effectively alleviate the symptoms of.4 patients with menopausal syndrome, TCM symptom score were compared: after treatment, TCM symptoms score decreased, statistically significant differences before and after the treatment (P0.01). XCD can reduce the symptoms of Chinese medicine, can effectively alleviate the symptoms of patients with kidney yin and Yang of the two virtual.5, compare the symptom score: after treatment of patients with symptom score before treatment under Drop, there were significant differences before and after the treatment (P0.01). XCD can reduce the symptom score, can effectively alleviate the symptoms of.6, the quality of life of tumor patients scale score: after treatment, the quality of life of patients with cancer patients score than before treatment decreased, there were significant differences before and after the treatment (P0.01 XCD). It can reduce the scores of quality of life of cancer patients, relieve the clinical symptoms of tumor patients, improve the quality of life of patients with.7, determine the security: Patients after treatment without obvious adverse reactions, no clinical adverse events before and after CA125 treatment. The serum NO abnormalities, no significant difference before and after treatment (P0.05). The liver function, renal function showed no abnormality. XCD treatment of ovarian cancer after menopause syndrome is safe. Conclusion: XCD can effectively alleviate the ovary The clinical symptoms of postmenopausal patients with menopause syndrome can improve the TCM syndrome of two deficiency of kidney yin and Yang, improve the quality of life of the patients, and have good safety.

【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.116

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