柴胡桂枝干姜汤对老年性感染后咳嗽气道神经源性炎性介质的影响

发布时间：2018-01-11 18:13

本文关键词：柴胡桂枝干姜汤对老年性感染后咳嗽气道神经源性炎性介质的影响　出处：《湖北中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：研究目的观察柴胡桂枝干姜汤对老年性感染后咳嗽患者气道神经源性炎性介质P物质、神经肽A、神经肽B水平的影响,探讨柴胡桂枝干姜汤治疗老年性感染后咳嗽的可能机制。研究方法将符合本课题研究的老年性感染后咳嗽患者,随机分为对照组和观察组,对照组采用西药复方甲氧那明胶囊口服治疗,观察组运用中药柴胡桂枝干姜汤化裁治疗,疗程均为3-5周。比较治疗前后两组患者咳嗽症状评分与咳嗽生活质量评分,分别采用ELISA法和夹心ELISA法检测治疗前后患者气道神经源性炎性介质P物质、神经肽A、神经肽B与分泌型免疫球蛋白A的含量。采用SPSS18.0统计学软件分析处理结果。研究结果1、临床疗效比较:经治疗后,两组患者日间、夜间咳嗽症状积分及咳嗽症状总积分均较治疗前下降,差异具有显著性统计学意义(P0.01);而且观察组患者日间咳嗽症状积分与咳嗽症状总积分均明显优于对照组,差异具有显著性统计学意义(P0.01),但夜间咳嗽症状积分与对照组比较无统计学意义(P0.05)。两组患者咳嗽生活质量评分均较治疗前上升,差异有显著性统计学意义(P0.01),且观察组咳嗽生活质量评分明显高于对照组生活质量评分,但差异无统计学意义(P0.05)。2、气道神经源性炎性介质的影响:经治疗后,两组患者气道神经源性炎性介质P物质、神经肽A、神经肽B的含量均较治疗前均有不同程度的下降,差异具有统计学意义(P0.05),而且与对照组比较,观察组患者的气道神经源性炎性介质P物质、神经肽A、神经肽B的水平下降更为显著,差异具有显著性统计学意义(P0.01)。3、气道分泌型免疫球蛋白的影响:与治疗前对比,观察组患者分泌型免疫球蛋白A的含量显著升高,差异具有统计学意义(P0.05),而且观察患者分泌型免疫球蛋白A的含量明显高于对照组,差异具有显著性统计学意义(P0.01),但对照组治疗前后分泌型免疫球蛋白A的含量比较,差异无统计学意义(P0.05)。结论柴胡桂枝干姜汤化裁治疗老年性感染后咳嗽,能够显著改善患者的咳嗽症状,提高患者的生活质量,增强患者的免疫功能,减少咳嗽的反复发生,这可能与其能降低气道神经源性炎性介质P物质、神经肽A、神经肽B的水平与提高气道分泌型免疫球蛋白A的水平有关。
[Abstract]:Objective to observe the effect of Chaihu Guizhi Ganjiang decoction on the levels of substance P, neuropeptide A and neuropeptide B in airway neurogenic inflammatory mediators in patients with cough after senile infection. To explore the possible mechanism of Chaihu Guizhi Ganjiang decoction in treating cough after senile infection. Methods the patients with senile post-infection cough were randomly divided into two groups: control group and observation group. The control group was treated with western medicine compound methoxysmin capsule orally, while the observation group was treated with traditional Chinese medicine Chaihu Guizhi dry ginger decoction. The course of treatment was 3-5 weeks. The scores of cough symptom and quality of life were compared between the two groups before and after treatment. The airway neurogenic inflammatory mediators substance P and neuropeptide A were detected by ELISA method and sandwich ELISA method before and after treatment. The content of neuropeptide B and secretory immunoglobulin A. the results were analyzed by SPSS18.0 software. 1. Comparison of clinical efficacy: after treatment, two groups of patients were treated during the day. The scores of nocturnal cough symptoms and the total score of cough symptoms were lower than those before treatment, and the difference was statistically significant (P 0.01). Moreover, the score of cough symptom and the total score of cough symptom in the observation group were significantly better than those in the control group, the difference was statistically significant (P 0.01). However, the score of nocturnal cough symptom was not significantly different from that of control group (P 0.05). The score of cough quality of life in both groups was higher than that before treatment, and the difference was statistically significant (P 0.01). The score of cough quality of life in the observation group was significantly higher than that in the control group, but the difference was not statistically significant (P0.05. 2). The effect of airway neurogenic inflammatory mediators: after treatment. The contents of substance P, neuropeptide A and neuropeptide B in airway neurogenic inflammatory mediators in the two groups were all decreased in varying degrees compared with those before treatment, and the difference was statistically significant (P 0.05). Compared with the control group, the levels of substance P, neuropeptide A and neuropeptide B in the airway neurogenic inflammatory mediators in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P 0.01). The effect of airway secretory immunoglobulin: compared with before treatment, the level of secretory immunoglobulin A in the observation group was significantly higher than that before treatment, the difference was statistically significant (P 0.05). The level of secretory immunoglobulin A in patients was significantly higher than that in the control group (P 0.01), but the level of secretory immunoglobulin A in the control group was higher than that in the control group before and after treatment. Conclusion Chaihu Guizhi dry Ginger decoction can significantly improve the cough symptoms and improve the quality of life of the patients after senile infection. Enhance the patient's immune function, reduce the recurrence of cough, which may reduce the airway neurogenic inflammatory mediator substance P, neuropeptide A. The level of neuropeptide B is related to the increase of airway secretory immunoglobulin A level.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.11

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