毫火针治疗白癜风多中心随机对照开放式优效性研究

发布时间：2018-01-12 02:07

本文关键词：毫火针治疗白癜风多中心随机对照开放式优效性研究　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察毫火针治疗白癜风的临床疗效和不良反应,来验证毫火针治疗白癜风的有效性及安全性。方法:采用计算机简单随机法,将40例白癜风患者分为两组:试验组20人,对照组20人,试验组外用0.1%他克莫司软膏联合毫火针治疗,对照组单纯外用0.1%他克莫司软膏,分别在治疗后4、8、12周进行疗效评价。治疗结束后随访1月。结果:对照组完成19例,试验组完成18例。首先,面积比较:治疗4、8、12周时,两组间白斑面积比较均采用独立样本t检验,差异均无统计学意义(P0.05);在对照组、试验组中,治疗前与治疗4、8、12周,白斑面积比较均采用配对t检验,差异有统计学意义(P0.05)。其次,疗效比较:对照组中,治疗4周,显效0例,好转8例,无效11例,显效率0,有效率42.000%;治疗8周,显效1例,好转12例,无效6例,显效率5.263%,有效率68.421%;治疗12周,显效3例,好转10例,无效6例,显效率15.789%,有效率68.421%。试验组中,治疗4周,显效2例,好转9例,无效7例,显效率11.111%,有效率61.111%;治疗8周,显效3例,好转14例,无效1例,显效率16.667%,有效率94.444%;治疗12周,显效6例,好转11例,无效1例,显效率33.333%,有效率94.444%。治疗4周,两组疗效比较采用秩和检验,差异无统计学(P0.05);治疗8、12周,两组疗效比较均采用了秩和检验,差异有统计学(P0.05)。最后,皮肤CT结果比较:经12周治疗后,试验组皮肤CT黑素细胞变化率为72.222%,对照组皮肤CT黑素细胞变化率为31.579%,两组皮肤CT结果比较经确切概率法检验,差异有统计学意义(P0.05)。结论:毫火针联合外用0.1%他克莫司软膏与单独外用0.1%他克莫司软膏治疗白癜风疾病均有一定疗效,毫火针联合外用0.1%他克莫司软膏较单独外用0.1%他克莫司软膏治疗白癜风疾病疗效更显著。然而,毫火针治疗白癜风的具体疗效有待进一步探究。
[Abstract]:Objective: to evaluate the efficacy and safety of neufire acupuncture in the treatment of vitiligo by observing the clinical efficacy and adverse reactions. Methods: a simple computer method was used to treat vitiligo. Forty patients with vitiligo were divided into two groups: experimental group (n = 20) and control group (n = 20). The experimental group was treated with 0.1% tacrolimus ointment combined with needling needle, and the control group was treated with 0.1% tacrolimus ointment. Results: 19 cases in control group and 18 cases in test group. First, area comparison: at 12 weeks after treatment, the area was compared: at 12 weeks after treatment, 19 cases were completed in the control group and 18 cases in the experimental group. First, the area comparison: at 12 weeks after treatment, 19 cases were completed in the control group and 18 cases in the experimental group. The white spot area of the two groups were compared by independent sample t test, and the difference was not statistically significant (P 0.05). In the control group, the experimental group, before treatment and treatment for 8 weeks 12 weeks, the white spot area was compared by paired t test, the difference was statistically significant (P 0.05). Second, comparison of efficacy: in the control group. After 4 weeks of treatment, there were significant effects in 0 cases, improvement in 8 cases, ineffective in 11 cases, marked rate of 0 and effective rate of 42,000; After 8 weeks of treatment, there were 1 case of remarkable effect, 12 cases of improvement and 6 cases of ineffectiveness. The effective rate was 5.263 and the effective rate was 68.421. After 12 weeks of treatment, there were 3 cases of marked effect, 10 cases of improvement, 6 cases of ineffectiveness, 15.789% of effective rate and 68.421% of effective rate. In the experimental group, there were 2 cases of remarkable effect, 9 cases of improvement and 7 cases of ineffectiveness. The effective rate is 11.111 and the effective rate is 61.111; After 8 weeks of treatment, there were 3 cases of remarkable effect, 14 cases of improvement and 1 case of ineffectiveness. The effective rate was 16.667% and the effective rate was 94.444%. After 12 weeks of treatment, there were 6 cases of marked effect, 11 cases of improvement, 1 case of ineffectiveness, 33.333% of marked rate and 94.4444% of effective rate. For 4 weeks, the curative effect of the two groups was compared by rank sum test. The difference was not significant (P 0.05). After 812 weeks of treatment, the two groups were treated with rank sum test, and the difference was statistically significant (P 0.05). Finally, the results of skin CT were compared: after 12 weeks of treatment. The change rate of CT melanocytes in the experimental group was 72.222 and that in the control group was 31.579.The results of CT in the two groups were compared by the exact probability method. Conclusion: the combination of 0.1% tacrolimus ointment and 0.1% tacrolimus ointment is effective in the treatment of vitiligo. 0.1% tacrolimus ointment was more effective than 0.1% tacrolimus ointment alone in the treatment of vitiligo.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R246.7

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