健胃化瘀汤治疗反复发作消化性溃疡脾虚血瘀证41例

发布时间：2018-01-13 12:00

本文关键词：健胃化瘀汤治疗反复发作消化性溃疡脾虚血瘀证41例　出处：《河南中医》2017年05期 　论文类型：期刊论文

【摘要】：目的:观察健胃化瘀汤治疗反复发作消化性溃疡脾虚血瘀证的临床疗效及对血清中碱性成纤维细胞生长因子(basic fibroblast growth factor,BFGF)和血管内皮细胞生长因子(vascular endothelial cell growth factor,VEGF)水平的影响。方法:将82例反复发作消化性溃疡患者随机分为治疗组和对照组各41例,对照组采用质子泵抑制剂(PPI)三联疗法,治疗组在对照组治疗的基础上采用健胃化瘀汤治疗,日1剂,常规水煮2次内服,两组疗程均为4周。比较两组患者治疗前后中医症状、胃和十二指肠黏膜损伤评分及临床疗效。检测两组患者血清BFGF和VEGF水平。结果:治疗后,治疗组中医症状评分、胃和十二指肠黏膜损伤评分明显低于对照组(P0.01);治疗组有效率为95.12%,优于对照组的75.61%(P0.05)。治疗组治疗后血清中BFGF和VEGF水平明显高于对照组(P0.01)。结论:健胃化瘀汤治疗反复发作消化性溃疡脾虚血瘀证疗效显著,其作用可能与提高血清中BFGF和VEGF水平有关。
[Abstract]:Objective: To observe the clinical effect of Jianwei Decoction Treating Recurrent Peptic Ulcer of spleen deficiency and blood stasis on basic fibroblast growth factor in serum (basic fibroblast growth factor, BFGF) and vascular endothelial growth factor (vascular endothelial cell growth factor, VEGF) level. Methods: 82 cases of patients with recurrent digestive ulcer were randomly divided into treatment group and control group with 41 cases in each group, the control group using proton pump inhibitors (PPI) triple therapy, treatment group with stomach Huayu Decoction based on the treatment in control group, day 1 agent, the conventional boiling 2 times orally, two groups were treated for 4 weeks. Two groups were compared before and after the treatment of TCM symptoms, gastric and duodenal mucosal injury score and clinical efficacy of two groups were detected. The serum BFGF and VEGF level. Results: after the treatment, the treatment group of TCM symptom score, gastric and intestinal mucosa injury on twelve fingers Was significantly lower than the control group (P0.01); the treatment group was 95.12%, better than 75.61% in the control group (P0.05). After treatment, the levels of BFGF and VEGF in serum were significantly higher than that of the control group (P0.01). Conclusion: Jianwei Decoction Treating Recurrent Peptic Ulcer of spleen deficiency and blood stasis syndrome significantly, which may be with the increased level of BFGF and VEGF in serum.

【作者单位】：罗山县卫生学校附属医院;河南中医药大学第三附属医院;
【基金】：河南省科技攻关重大项目(编号:112101310200)
【分类号】：R259
【正文快照】： 本文引用:梅世明,王红玲.健胃化瘀汤治疗反复发作消化性溃疡脾虚血瘀证41例[J].河南中医,2017,37(5):833-835.消化性溃疡是临床常见多发性慢性病,大部分患者经幽门螺杆菌根除或/和强力抑酸治疗可达到溃疡愈合的效果[1]。然而仍有部分消化性溃疡患者对常规干预措施的效果较差,

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