藿钩退热散直肠滴注治疗小儿外感发热（外寒内热证）的临床观察

发布时间：2018-01-14 07:45

本文关键词：藿钩退热散直肠滴注治疗小儿外感发热（外寒内热证）的临床观察　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察藿钩退热散直肠给药治疗小儿外感发热(外寒内热证)的临床疗效和安全性,并对其作用机制做进一步的探讨。方法:将满足诊断标准的患儿共60例,按随机原则分为两组,其中治疗组(藿钩退热散直肠滴注组)30例,对照组(藿钩退热散口服给药组)30例。治疗3天后,对两组患儿在临床总疗效、中医证候积分改善、起效时间、发热终止时间等进行比较。结果:1.以藿钩退热散直肠滴注的方法治疗小儿外感发热(外寒内热证)治疗组临床疗效总有效率为100.0%,治疗组治愈率为73.33%;对照组临床总有效率为100.00%,对照组治愈率为76.67%。经统计学分析,两组临床疗效无明显差别(P㧐0.05)。2.在中医证候改善上,治疗组治疗前主症积分值为9.70±2.64,治疗后为0.60±1.07,对照组治疗前主症积分值为8.93±2.77,治疗后为0.47±1.01,两组主症积分值治疗前后比较均有统计学差异(P㩳0.01),两组之间治疗前后主症积分值比较均无统计学差异(P㧐0.05),两组治疗方法对于中医主症证候积分的改善情况相同。治疗组治疗前总积分值为17.60±4.68,治疗后为1.20±2.22,对照组治疗前总积分值为17.50±4.27,治疗后为0.67±1.12,两组总积分值治疗前后比较均有显著统计学差异(P㩳0.01),两组之间治疗后总积分值比较无明显统计学差异(P㧐0.05),两组治疗方法对于中医证候总积分的改善情况相同。3.在起效时间上,治疗组平均时间为(2.23±1.17)小时,对照组为(3.47±1.55)小时,两组在起效时间上经统计学检验P0.05,说明两组退热起效时间差异具有统计学意义,且治疗组优于对照组。4.在痊愈患儿的发热完全停止时间上,治疗组为(50.87±12.78)小时,对照组为(51.60±16.45)小时,两组发热停止时间经统计学分析P㧐0.05,二者比较无明显差异,说明两种治疗方式疗程相同。结论:藿钩退热散直肠滴注法治疗小儿外感发热(外寒内热证)疗效与藿钩退热散口服给药法无明显差异,但患儿对直肠滴注法的接受度较口服法高。
[Abstract]:Objective: to observe the clinical efficacy and safety of Huoku antipyretic powder rectal administration in the treatment of children with exogenous fever (external cold and internal heat syndrome). Methods: 60 cases of children who met the diagnostic criteria were divided into two groups according to the random principle, including 30 cases in the treatment group (Huohook antipyretic powder rectal drip group). Control group (Huoku antipyretic powder oral administration group of 30 cases. After 3 days of treatment, the two groups of children in the clinical efficacy, TCM syndromes integral improvement, effective time. Results 1. The total effective rate was 100.0% in the treatment group of children with exogenous fever (external cold and internal heat syndrome) by rectal drip of Huohook antipyretic powder. The cure rate of treatment group was 73.33. The total effective rate in the control group was 100.00g and the cure rate in the control group was 76.67.The statistical analysis showed that there was no significant difference in the clinical efficacy between the two groups. In the improvement of TCM syndromes, the integral value of main symptoms in the treatment group was 9.70 卤2.64 before treatment and 0.60 卤1.07 after treatment. The score of main symptom in control group was 8.93 卤2.77 before treatment and 0.47 卤1.01after treatment. There was statistical difference between the two groups before and after treatment. There was no significant difference in the scores of main symptoms between the two groups before and after treatment. The total integral value of treatment group was 17.60 卤4.68 before treatment and 1.20 卤2.22 after treatment. The total integral value of control group was 17.50 卤4.27 before treatment and 0.67 卤1.12 after treatment. There was no significant difference in the total integral value between the two groups after treatment. The improvement of the total integral of TCM syndromes was the same between the two groups. The average time of the treatment group was 2.23 卤1.17 hours. The control group was 3.47 卤1.55 hours, the two groups in the effective time by statistical test (P0.05), indicating that the two groups of antipyretic onset time difference was statistically significant. And the treatment group was superior to the control group. 4. The time of complete cessation of fever in the cured children was 50.87 卤12.78 hours in the treatment group and 51.60 卤16.45 hours in the control group. The stopping time of fever in the two groups was statistically analyzed (P? There was no significant difference between the two groups. Conclusion: there is no significant difference between the two methods in the treatment of children's external fever (external cold and internal heat syndrome) and oral administration of Huoku antipyretic powder. However, the acceptance of rectal drip was higher in children than in oral.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R272

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