五味消渴方治疗气阴两虚证2型糖尿病患者临床观察

发布时间：2018-01-14 19:02

本文关键词：五味消渴方治疗气阴两虚证2型糖尿病患者临床观察　出处：《中国实验方剂学杂志》2017年24期 　论文类型：期刊论文

【摘要】：目的:观察五味消渴方治疗2型糖尿病气阴两虚证的临床疗效,并探讨其作用机制。方法:选取128例2型糖尿病气阴两虚证患者,随机分为治疗组(64例)和对照组(64例),治疗组采用五味消渴方+基础治疗,对照组采用安慰剂+基础治疗,观察治疗前后患者症状、体征变化,检测空腹血糖(FBG),餐后2 h血糖(P2 hBG),糖化血红蛋白(HbA1c),空腹血清胰岛素(FINS),安全性指标(血、尿、便常规,肝、肾功能),计算胰岛素抵抗指数(HOMA-IR),中医证候评分。结果:两组患者分配均衡,基线状况良好,可比性强。中医证候方面,两组患者口渴喜饮、多食易饥、气短懒言、倦怠乏力、心悸失眠、五心烦热、舌红少津、脉细数无力均明显改善,治疗组优于对照组(P0.05);治疗组和对照组中医疗效总有效率分别为93.55%,76.19%,治疗组优于对照组(P0.05);两组患者治疗后FBG,P2 hBG,HbA1c,FINS,HOMA-IR均较治疗前改善,治疗组改善更明显(P0.05)。结论:五味消渴方治疗2型糖尿病气阴两虚证疗效显著且安全,值得推广应用。
[Abstract]:Objective: To observe the clinical curative effect of five kinds of Xiaoke Decoction in the treatment of Qi and yin deficiency of type 2 diabetes, and explore its mechanism. Methods: 128 patients with type 2 diabetes mellitus two Qi and yin deficiency syndrome patients were randomly divided into treatment group (64 cases) and control group (64 cases), treatment group with five kinds of Xiaoke Decoction plus basic treatment and the control group with placebo plus basic treatment, patients were observed before and after treatment of symptoms, signs of change, fasting blood glucose (FBG), 2 h postprandial blood glucose (P2 hBG), glycosylated hemoglobin (HbA1c), fasting serum insulin (FINS), safety indicators (blood, urine, stool, liver and kidney function) and the insulin resistance index (HOMA-IR), TCM syndrome score. Results: two groups of patients with balanced distribution, good baseline, comparability. TCM syndrome, two patients thirsty to drink, eat easy to hunger, shortness of breath, fatigue, palpitations, insomnia, five upset hot, red tongue Shaojin, thready pulse weakness significantly Improvement in the treatment group than the control group (P0.05); Chinese medicine treatment group and the control group the total effective rates were 93.55%, 76.19%, the treatment group than the control group (P0.05); the two groups of patients after treatment of FBG, P2, hBG, HbA1c, FINS, HOMA-IR were improved compared with before treatment, the treatment group improved more significantly (P0.05). Conclusion: five kinds of diabetes treatment efficacy of Qi and yin deficiency of type 2 diabetes was remarkable and safe, it is worthy of popularization and application.

【作者单位】：广西中医药大学;广西中医药大学第一附属医院;
【基金】：国家自然科学基金项目(81560520) 广西研究生教育创新计划项目(YJS201641)
【分类号】：R259
【正文快照】： [网络出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170926.1102.040.html[网络出版时间]2017-09-26 11:02糖尿病是一组以高血糖为特征的代谢性疾病,是由胰岛素分泌缺陷或(和)其生物作用受损引起[1-2]。糖尿病易引起心、肾等多系统并发症,具有高致残率、高致死率和

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