疏肝理气活血法治疗气滞血瘀型冠心病稳定型心绞痛的临床研究

发布时间：2018-01-15 21:03

本文关键词：疏肝理气活血法治疗气滞血瘀型冠心病稳定型心绞痛的临床研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察逍遥红花煎加味对气滞血瘀型冠心病稳定型心绞痛患者的临床治疗疗效,探讨逍遥红花煎的作用机制,评价其疗效及安全性,拟为临床治疗冠心病稳定型心绞痛提供实际而有价值的治疗途径。方法:按照纳入标准和排除标准选取山东中医药大学第一附属医院—山东省中医院60例综合内科、心内科门诊及住院病人,采用前瞻性的随机对照研究,随机分为试验组和对照组各30例。对照组采用一般治疗和常规西医治疗,实验组在对照组治疗的基础上加用逍遥红花煎加味,一日一剂,早晚饭后半小时温服。治疗4周后进行临床疗效评定。分别于治疗前、后行一般检查项目:心率、血压、空腹血糖、血脂、肝功、肾功等。观察两组患者治疗前后的心电图变化、心绞痛发作情况、硝酸甘油减停率、症状严重程度、中医症状总评分、中医总疗效、单项症状疗效判定等,从而评价总体疗效及安全性。结果:经过4周治疗后,对比两组临床疗效,试验组在改善心绞痛的发作情况(疼痛程度、发作频率、发作持续时间)方面疗效优于对照组(P0.05),中医症状评分明显改善(P0.05),在硝酸甘油停减率、心电图变化等相关辅助检查指标方面,试验组明显优于对照组(P0.05)。总体比较,各项疗效结果试验组均优于对照组。肝肾功能等安全性指标治疗前后无明显变化,无统计学差异,应用安全;在血压、空腹血糖方面,无统计学差异。结论:本研究经临床试验验证及统计学分析得出逍遥红花煎加味能有效改善气滞血瘀型冠心病稳定型心绞痛患者的临床症状,并能提高患者的生活质量,具有良好的安全性和耐受性,对治疗此类型的冠心病心绞痛具有重要的临床指导意义,值得进一步应用和推广。
[Abstract]:Objective: to observe the clinical therapeutic effect of Xiaoyao Honghua decoction on stable angina pectoris of coronary heart disease with Qi stagnation and blood stasis type, to explore the mechanism of Xiaoyao safflower decoction, and to evaluate its efficacy and safety. To provide a practical and valuable therapeutic approach for stable angina pectoris of coronary heart disease. According to the criteria of inclusion and exclusion, 60 cases of general internal medicine were selected from Shandong Provincial traditional Chinese Medicine Hospital, the first affiliated hospital of Shandong University of traditional Chinese Medicine. The outpatients and inpatients in the department of cardiology were randomly divided into two groups: the experimental group (n = 30) and the control group (n = 30). The control group was treated with general treatment and conventional western medicine. The experimental group in the control group on the basis of the treatment plus Xiaoyao safflower decoction added, 1st, one dose, morning and evening half an hour after meals warm. 4 weeks after the treatment of clinical efficacy evaluation, respectively before treatment. After the general examination items: heart rate, blood pressure, fasting blood glucose, blood lipid, liver function, renal function and so on. Observe the two groups of patients before and after treatment of ECG changes, angina pectoris attack, nitroglycerin reduction rate, symptom severity. The total score of TCM symptom, the total curative effect of TCM, the judgment of single symptom curative effect and so on, so as to evaluate the overall curative effect and safety. Results: after 4 weeks of treatment, the two groups were compared with each other in clinical efficacy. The treatment group was better than the control group in improving the attack of angina pectoris (pain degree, attack frequency, attack duration), and the TCM symptom score was significantly improved (P0.05). The test group was superior to the control group (P 0.05) in the related auxiliary examination indexes such as the stopping and decreasing rate of nitroglycerin and the change of electrocardiogram. The safety indexes such as liver and kidney function had no obvious change before and after treatment, there was no statistical difference, and it was safe to use. In terms of blood pressure, fasting blood sugar. No statistical difference. Conclusion: this study through clinical trials and statistical analysis of Xiaoyao safflower decoction can effectively improve the clinical symptoms of patients with stable angina pectoris of Qi-stagnation and blood stasis type coronary heart disease. It can improve the quality of life of patients and has good safety and tolerance. It has important clinical significance for the treatment of angina pectoris of coronary heart disease and is worthy of further application and promotion.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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