基于关联规则挖掘健脾中药对湿热痹阻型类风湿关节炎患者免疫炎症的影响

发布时间：2018-01-16 02:11

本文关键词：基于关联规则挖掘健脾中药对湿热痹阻型类风湿关节炎患者免疫炎症的影响　出处：《时珍国医国药》2017年04期 　论文类型：期刊论文

【摘要】：目的应用关联规则和统计学方法分析风湿病科治疗湿热痹阻型类风湿关节炎所用健脾中药对患者免疫炎症的影响,探讨从脾论治RA的科学性。方法整理安徽中医药大学第一附属医院风湿病科2012年6月至2015年10月湿热痹阻型类风湿关节炎住院患者的病历资料。采用SPSS 17.0和SPSS Clementine 12.0软件Aprior模块分析健脾中药对患者免疫炎症的影响。结果湿热痹阻型RA患者所用健脾中药频次80%以上有茯苓、薏苡仁、陈皮,茯苓、薏苡仁、陈皮与RF、ESR、SOD、CCP-AB等指标存在明显关联关系,其中薏苡仁与各指标关联置信度居高,且和祛风除湿药、清热解毒药合用与各指标关联置信度提高,对照组治疗后RF较治疗前降低,治疗组治疗后RF、Hs-CRP、ESR、CCP-AB、PLT较治疗前有明显降低,SOD明显升高,治疗组治疗后RF、Hs-CRP、ESR较对照组治疗后降低明显,差异有统计学意义(P0.05或P0.01)。结论薏苡仁等健脾中药可有效调节湿热痹阻型RA患者免疫炎症反应,提高机体抗氧化能力,辨证施治合理组方亦为重要。
[Abstract]:Objective to analyze the effect of spleen tonifying traditional Chinese medicine (TCM) on immune inflammation in patients with rheumatoid arthritis treated by rheumatology with association rules and statistical methods. Methods the medical records of patients with rheumatoid arthritis in the first affiliated Hospital of Anhui University of traditional Chinese Medicine from June 2012 to October 2015 were collected from the Department of Rheumatology of the Department of Rheumatology of the first affiliated Hospital of Anhui University of traditional Chinese Medicine from June 2012 to October 2015. Adopt SPSS. 17.0 and SPSS Clementine. Results the frequency of traditional Chinese medicine for strengthening spleen was more than 80% times in RA patients with damp-heat arthralgia. Coix seed, pericarp, Poria cocos, Coix seed, old pericarp and RFS ESRD SODX CCP-AB were significantly correlated, among which Coix seed had high confidence with each index. In addition, the confidence degree of the combination of antiwind and dehumidification drugs, heat clearing and detoxifying drugs with each index was increased, the RF of the control group was lower than that of the control group, and that of the treatment group after treatment was lower than that of the control group, and the CCP-AB of the treatment group after treatment. Compared with before treatment, PLT was significantly decreased, and Hs-CRP was significantly decreased in the treatment group than that in the control group. Conclusion Coix seed can effectively regulate the immune inflammatory response of RA patients with damp-heat arthralgia and improve the antioxidant capacity of the body. Dialectical treatment of rational prescription is also important.
【作者单位】：安徽中医药大学研究生院;安徽中医药大学第一附属医院;
【基金】：国家中医药重点学科中医痹病学建设项目(国中医药发[2009]30号) 国家临床重点专科中医风湿病科建设项目(财社[2013]239号) 安徽省重点实验室建设项目(1306c083035) 国家科技支撑计划课题(2012BA126B02) 国家自然基金青年项目(81403388)
【分类号】：R259
【正文快照】： 国家自然基金青年项目(81403388)。类风湿关节炎(rheumatoid arthritis,RA)是以滑膜炎为特征的全身性免疫性疾病。研究表明,RA的中医基本病机是气血不足、脾虚湿盛、痰瘀互结,健脾化湿是其治本之法[1]。氧化应激和免疫炎症反应共同参与RA的发病过程,细胞因子失衡贯穿全程,氧化

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