参蛭通心胶囊合葶苈大枣泻肺汤治疗气虚血瘀，阳虚水泛型慢性心力衰竭的临床研究

发布时间：2018-01-16 07:08

本文关键词：参蛭通心胶囊合葶苈大枣泻肺汤治疗气虚血瘀，阳虚水泛型慢性心力衰竭的临床研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察参蛭通心胶囊合葶苈大枣泻肺汤对气虚血瘀,阳虚水泛型慢性收缩性心力衰竭的临床治疗效果。方法:遵循随机、对照的原则,选取山东中医药大学附属医院心内科慢性收缩性心力衰竭患者60例,随机分成试验组30例和对照组30例,根据2014年版《中国心力衰竭诊断和治疗指南》,常规给以ACEI(血管紧张素转换酶抑制剂)治疗,对ACEI不耐受者给与ARB(血管紧张素受体拮抗剂)治疗,以及β-受体阻滞剂(β-receptor blocker)、醛固酮受体拮抗剂、利尿剂、强心甙类药物等西药治疗,试验组除给与西药治疗外,加用参蛭通心胶囊合葶苈大枣泻肺汤治疗,2组均治疗4周观察疗效。观察治疗前后的中医证侯积分、LVEF(左心室射血分数)、NT-proBNP(N末端脑钠肽原)、6MWT(6分钟步行距离)、心功能分级等变化。结果:两组的中医证侯积分、LVEF、NT-proBNP、6MWT、心功能分级均有改善,试验组的疗效明显优于对照组,两者具有统计学差异(P0.05).60例患者在治疗前后血常规和肝肾功检测均无异常。结论:参蛭通心胶囊合葶苈大枣泻肺汤可改善气虚血瘀,阳虚水泛型慢性心力衰竭患者临床症状,提高患者的生活质量,安全性和依从性好。
[Abstract]:Objective: to observe the clinical effect of Shenzhi Tongxin capsule combined with Tinglidazaoxiefeng decoction on chronic systolic heart failure with Qi deficiency and blood stasis, Yang deficiency water generality. Methods: to follow the principle of randomness and control. Sixty patients with chronic systolic heart failure (CHF) in Department of Cardiology, affiliated Hospital of Shandong University of traditional Chinese Medicine, were randomly divided into experimental group (n = 30) and control group (n = 30). According to the 2014 edition of the guidelines for the diagnosis and treatment of Heart failure in China, ACEI (angiotensin converting enzyme inhibitor) is routinely administered. Patients with ACEI intolerance were treated with ACEI (angiotensin receptor antagonist) and 尾 -receptor blocker (尾 -receptor blocker). Diuretics, cardioside drugs and other western medicine treatment, the experimental group in addition to western medicine treatment, plus Shenzhi Tongxin capsule and Tingdazao Xiefei decoction treatment. The therapeutic effect was observed for 4 weeks in both groups, and the LVEF (left ventricular ejection fraction) was observed before and after treatment, and the NT-proBNPN N-terminal brain natriuretic peptide (NT-proBNPN) was observed. Results: LVEFN NT-proBNPN 6MWT6 MWT6 minutes walking distance, cardiac function grading and so on. Results: the score of LVEFNT-proBNPN 6MWTwas improved in both groups. The curative effect of the test group was better than that of the control group. There was statistical difference between the two groups. 60 patients had no abnormal blood routine and liver and kidney function before and after treatment. Conclusion: Shenzhi Tongxin capsule combined with Tingli Da Zao Xiefei decoction can improve qi deficiency and blood stasis. The clinical symptoms of patients with chronic heart failure due to yang deficiency and water deficiency can improve their quality of life, safety and compliance.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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