针灸疗法对急性脑梗死后抑郁患者临床疗效及血清VEGF水平的影响研究

发布时间：2018-01-16 09:27

本文关键词：针灸疗法对急性脑梗死后抑郁患者临床疗效及血清VEGF水平的影响研究　出处：《当代医学》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨针灸疗法对急性脑梗塞后抑郁患者的临床疗效及对血清中血管内皮生长因子(VEGF)水平变化的影响。方法将82例患者随机分为两组,对照组给予赛乐特(盐酸帕罗西汀片)治疗,治疗组接受赛乐特和针灸治疗,疗程为4周。采用在治疗前后进行汉密尔顿抑郁量表(HAMD)评定及血清VEGF的测定,酶联免疫吸附法(ELISA)测定VEGF,统计学采用t检验和c2检验。结果经过4周的治疗后,HAMD评分经针灸治疗后减分明显,治疗组总有效率80.49%,对照组总有效率51.22%。血清VEGF水平治疗组(298.11±56.23)pg/mL和正常对照组(203.32±27.16)pg/mL相比,差异有统计学意义(P0.05)。VEGF水平在针灸治疗后有显著性提高,差异有统计学意义(P0.05)。结论针灸治疗脑梗死伴发抑郁症较单用西药治疗有较好的疗效并且可以提高血清VEGF水平。
[Abstract]:Objective to investigate the clinical effect of acupuncture therapy on depression in patients with acute cerebral infarction and serum vascular endothelial growth factor (VEGF) level changes. Methods 82 patients were randomly divided into two groups, the control group was given paroxetine (Paroxetine Hydrochloride Tablets) treatment, the treatment group received paroxetine and acupuncture treatment, the treatment for 4 weeks. The Hamilton Depression Scale (HAMD) before and after treatment were assessed and serum VEGF, enzyme-linked immunosorbent assay (ELISA) determination of VEGF, statistics by t test and C2 test. Results after 4 weeks of treatment, HAMD score decreased significantly after acupuncture therapy, the treatment group total effectiveness 80.49%, control group the total serum VEGF level 51.22%. rate in the treatment group (298.11 + 56.23) pg/mL group and normal control group (203.32 + 27.16) compared to pg/mL, the difference was statistically significant (P0.05) the level of.VEGF increased significantly in the acupuncture treatment, there are differences Statistical significance (P0.05). Conclusion acupuncture and moxibustion treatment of cerebral infarction with depression is better than only western medicine and can improve the level of serum VEGF.

【作者单位】：青岛海慈医疗集团神经内科;
【分类号】：R246.6
【正文快照】： 脑梗死后抑郁是常见并发症,影响患者生活质量和疾病的康复。近年来人们发现针灸治疗有改善记忆及认知功能、抑郁状态等作用。在众多神经营养因子中,VEGF是一种多功能的因子,近几年VEGF与抑郁症发生及抗抑郁治疗的密切关系倍受关注[1]。本研究主要探讨针灸对脑梗死伴发抑郁症治

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